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Relationship among concentrations of brain natriuretic peptide,C reactive protein,nitric oxide and heart failure

LU Hai-ling,LONG Yun-ling,PENG Xiang-nan,CHEN Shi-feng,DENG Shao-lun,CHEN Long-jun//Department of Internal Medicine,Affiliated Hospital of Medical School of Beihai City,Hepu,Guangxi,536100,China  
Objective:To investigate changes of serum concentrations of brain natriuretic peptide(BNP),C-reactive protein(CRP) and nitric oxide(NO) in different degrees of heart failure(HF) and their relationship with HF.Methods:A total of 51 HF patients were divided into three groups(NYHA classⅡgroup~Ⅳgruop) according to New York heart association(NYHA) classification standards,and another 27 cases were enrolled as normal control group.Serum concentrations of BNP,CRP and NO were measured,and multivariate analysis of variance and partial correlation analysis were performed on the results.Results:Levels of BNP [(18.35±19.42)pg/ml vs.(62.34±67.34)pg/ml vs.(70.03±44.49)pg/ml vs.(99.87±83.08)pg/ml],CRP[(4.42±5.94)mg/ml vs.(19.73±36.65)mg/ml vs.(25.31±47.26)mg/ml vs.(18.20±41.53)mg/ml] and NO[(143.17±78.62)μmol/L vs.(158.69±131.40)μmol/L vs.(165.29±197.46)μmol/L vs.(133.93±117.06)μmol/L] showed overall significant difference among normal control and HF groups(P0.05 all).Partial correlation analysis showed that serum BNP was negatively correlated with NO(r=-0.0240,P0.05).Conclusion:Changes of serum concentrations of brain natriuretic peptide,C reactive protein and nitric oxide show overall significant difference and correlation among normal people and patients with different degrees of heart failure.Detection of them in clinic is helpful to diagnose heart failure and determine the degree of heart failure.
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