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《World Chinese Journal of Digestology》 2001-10
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Effects of acu-poin electro-acupun cture on gastrointentinal mucosa immunologic function in rats

Jing Zhang Yu-Xin Hang Wei Gao Jing-Jie Wang Yan-Mei Li Qing-Li Wang Department of Gastroenterology,Tangdu HospitalBo-Rong Pan Department of Oncology,Xijing Hospital,Fourth Military Medicall University,Xi,an 710038,Shaanxi Province,China Correspondence to:Yu Xin Huang,Department of Gastroentreology,Tangdu Hospital,Fourth Military Medical University,Xi,an 710038,  
AIM To explore the effect of electro-acupuncture on gestrointentinal mucosal immunologic function. METHODS 32 SD rats were randomly divided into 4 groups,acupuncure different acupuncture point.The contents of secretory immunolgobulim A(slgA)in peripheral blood,gastric and intestinal tissues were determined by immunologic radioimmunoaesay(IRMA). Also intraepithelial lymphocyte(IEL)and laminia propria lymphocyles(LPLs),proliferations were determined by mononuclear cell cytotoxicity aesay(MTT). PESULTS The contents of algA in peripheral blood, gastric,and intestinal tissues and IELs and LPLs proliferation in zusanli group were sinificantly higher than those of control group(55 vs 32 mg·L~(-1);1759 vs 1163ug· g~(-1);1403 vs 1016ug·g~(-1);1.60 vs 1.15;1.61 vs 1.16;1. 53 vs 1.03;1.53 vs 1.05,P≤0.01.The contents of slgA in inteseines in shangjuxu group were significantly higher than that in control group(1388 vs 1016ug·g~(-1),P0.01 ,the contents of slgA in peripheral blood and gastric tissue,IELs and LPLs proliferation was not statistically different between acupuncture group and control group(P 0.05). CONCLUSIONS Electro-acupuncture into zusanli may improve slgA contents in peripheral blood,gastric and Intestinal tlestes,and IEL and LPL,s proliferations were improved too.So electro-acupuncture can improve gastrointentinal mucosa immunologic function,which may have important significance in the clinical therapy with acupuncture,
【Fund】: 国家自然科学基金资组项目 No.39970888
【CateGory Index】: R245
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