Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《World Chinese Journal of Digestology》 2002-03
Add to Favorite Get Latest Update

Effect of weishusan on patients with functional dyspepsia and H. pylori infection

Ling-Fei Wu, Zong-Mao Zheng, Guo-Ping Li, Bing-Zhou Wang, Hai-Yong Than, The Zeng, Ze-Qing Zhou, Department of Gsatroenterology, Second Affiliated Hospital, Shantou University Medical College, Shantou 515041, Guangdong Province, China  
AIM: To evaluate the efficacy of weishusan on functional dyspepsia and to investigate the potential effect of eradication of H. pylori on gastritis and symptomatology of H. pylori -positive dyspepsia.METHODS: Total 87 patients with functional dyspepsia were randomized to receive weishusan (3. 0 tid, n = 56) or mosapride (5 mg tid, n = 31) for 4 weeks. The symptom score and severity of gastritis were assessed by clinical practitioners and endoscopy separately. Serum motilin (Mot), gastrin (Gas) and H. pylori were detected.RESULTS: Symptom improvement was significant in weishusan group and mosapride group (85.7 % vs 80.6 %, NS). The motilin level was significantly higher after treatment in both groups (457 ± 119 ng· L-1 vs 410 ± 106 ng· L-1, P 0. 01). The total effective rate of gastritis improvement in weishusan group (57.7 %) was significantly higher than that in mosapride group (20.7 %, P 0.01). Regarding H. pylori status, eradication of H. pylori was achieved in 41.9 % (18/ 31) in weishusan group and no one in mosapride group (0/14,0%, P0.01). No differences in the symptom score improvement were observed between patients with eradication, persistent infection and without infection. The gastritis improvement in patients with eradication (83. 8 %) was significantly higher than those without infection (47.2 %, P 0. 05), and those persistent infection (14.8 %, P0.01). The gastrin level in H. pylori positive patients was significantly higher than that in H. pylori negative patients (47 ± 17 ng· L-1 vs 36 ± 13 ng· L-1 P 0.05). After eradication the gastrin level decreased but no significant differences were observed (P 0.05).CONCLUSION :Weishusan is a good prokinetic drug and has effect on functional dyspepsia. It also has effects on protection of gastric mucosa and on eradication of H. pylori, which seems not to contribute to the timely symptom improvement of dyspepsia.
【Fund】: 广东省中医药管理局资助项目 No.99591
【CateGory Index】: R57
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved