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Relationship between morphological characteristics of tumor microvessel and biological features of primary hepatocellular carcinoma

Gong-Jie Li, Fu-Geng Sheng, Peng-Gang Qiao, Department of Radiology, the 307 Hospital of Chinese PLA, Beijing 100039, China Li Yang, Department of Radiology, the 301 Hospital of Chinese PLA, Beijing 100853, China Xiao-Lin Shi, Department of Gastroenterology, the 301 Hospital of Chinese PLA, Beijing 100853, China  
AIM: To investigate the relationship between the tumor microvascular characteristics and biological features of primary hepatocellular carcinoma (HCC). METHODS: Thirty-two tumor specimens were resected from patients with HCC. The tumor microvessel density (MVD), microvessel diameter (MD), trabecular diameter (TD) and diameter ratio of tumor microvessel to trabecular (D-TM/T) of HCC with different differentiated degree, sizes, and blood supply in DSA were analyzed statistically. RESULTS: The grades of tumor microvessel type tended to go up with the growth of HCC (rs= 0.55,P= 0.001). With the increase of tumor microvessel grades, DSA blood supply tended to be higher types (rs= 0.56, P= 0.001). MVD was different between different sizes of HCC, and the highest value, which was significantly higher than that of HCC with the diameters of≤3 cm (P= 0.005) and 5 cm (P= 0.016), appeared in tumors with the diameters of 3- 5 cm. MD was increased with the increase of HCC diameter. MVDs in low, moderate and high blood supply HCC were 45.34±21.18, 69.50±54.18 and 61.56±38.94 respectively, and MVD in low blood supply HCC was much markedly lower than that in moderate and high one (P= 0.014, P=0.031). Tumor MD and D-TM/T was increased from low to high blood supply HCC accordingly. Tumor MD of low blood supply HCC was significantly smaller than that in high one (P= 0.044), and D-TM/T obviously lower than moderate and high one (P= 0.017, P= 0.008). MVD showed no significant difference between high and moderate blood supply HCC.MVD was not significantly related to the differentiated degree of HCC (P0.05). CONCLUSION: The characteristics of tumor microvessels are regularly different during the progress of HCC. HCC with different blood supply shows significant differences in features of tumor microvessels.
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