Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《World Chinese Journal of Digestology》 2005-21
Add to Favorite Get Latest Update

Inhibitory effects of Ginkgo biloba leaf flavonoids on proliferation of human gastric cancer cell line BGC823 in vitro

Feng Zhang, Gui-Wen Yang, Jin-Feng Zhang, Li-Guo An, Key Laboratory of Animal Resistance, College of Life Sciences, Shandong Normal University, Jinan 250014, Shandong Province, China  
AIM: To extract the avonoids from Ginkgo biloba leaf, and to investigate its inhibitroy effects on the prolifera- tion of human gastric cancer cell line BGC823 cultured in vitro. METHODS: Ethanol (700 mL/L) was used to extract the flavonoids from the leaf of Ginkgo biloba. Three wavelength spectrophotometry was used to determine the content of avonoids in the extracts. Human gastric cancer cells BGC823 cultured in vitro were treated with different concentrations of the avonoids, and then the proliferation of the cells was detected by MTT assay and ow cytometry. RESULTS: The content of flavonoids in the extracts was 140 mg/g. The avonoids from Ginkgo biloba leaf inhibited the proliferation of BGC823 cells in a dose- dependent manner. The rate of cells in S phase was notably increased as compared with that in the controls (42.17±0.50% vs 32.13±0.45%, P = 0.001), and the ap- optotic rate of the cells was also increased (4.10±0.03% vs 2.21±0.01%, P = 0.002). CONCLUSION: Ginkgo biloba leaf avonoids can in- hibit the proliferation of human gastric cancer cell line BGC823 by affecting the cycle the cells.
【CateGory Index】: R735.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 10 Hits
1 HAO Yan-zhi et al(School Hospital of Qingdao Agricultural University,Qingdao,Shandong 266109);Inhibitory Effects of Composite PSP on HeLa Cells of Human Cervical Cancer[J];Journal of Anhui Agricultural Sciences;2009-08
2 YU Lin-hua,WANG Yi-qiang,LAN Hua,WANG Shuang (College of Life Science and Technology,Central South University of Forestry and Technology,Changsha,Hunan 410004);Research Progress on Pharmacological Functions of Folium Ginkgo or Extract of Ginkgo biloba[J];Northern Horticulture;2011-10
3 GENG Xiu-fang1,YANG Li-li1,PANG Zhi-fang1,LIU Hong-ying1,WANG Chang-liang2(1.Weifang Medical University,Weifang 261041,Shandong,China;2.Weifang People′s Hospital,Weifang 261041,Shandong,China);Effects of total flavonoids in Ginkgo biloba leaves on proliferation and apoptosis of human liver cancer cell line HepG2 in vitro[J];Journal of Medical Postgraduates;2010-06
4 FANG Jing,TAN Wei-hong(Institute of Chemical Industry of Forest Products,CAF;Key and Open Lab.on Forest Chemical Engineering,SFA,Nanjing 210042,China);Research Progress on Anti-tumor Compounds from Ginkgo biloba Extracts[J];Biomass Chemical Engineering;2008-05
5 YANG Li-li~1,GENG Xiu-fang~2,LIU Hong-ying~1,PAN Zhi-fang~3,LIU Shun-mei~1(1 The Genetics Department of Weifang Medical College,Weifang 261053,China;2 The Biochemistry Departmentof Weifang Medical College;3 The Cell Biology Department of Weifang Medical College);The Effect of Ginkgo Biloba Leaf Flavonoids and Quercetin on Proliferation and Apoptosis of Human Liver Cancer Cell Line HepG2[J];Acta Academiae Medicinae Weifang;2009-02
6 Zhang Zhijuan Qiao Mingxia Hao Yanzhi et al College of Life Science,Qingdao Agricultural University (Qingdao 266109);Anti-tumor effects of compound PSP on 7402 cells[J];Shaanxi Medical Journal;2009-03
7 Peng Jiao, Ming-Feng Yang, Feng Zhang, Xiao-Min Zhao, Institute of Life Sciences, Taishan Medical College, Tai'an 271000, Shandong Province, China Qi Chang, Department of Personnel, the Affiliated Hospital of Taishan Medical College, Tai'an 271000, Shandong Province, China Zuo-Li Xia, Key Laboratory of Microcirculatory, Taishan Medical College, Tai'an 271000, Shandong Province, China;Effects of SaMa miltiorrhiza Bge.f.alba root preparation on the proliferation and apoptosis of gastric cancer cells[J];World Chinese Journal of Digestology;2007-08
8 YANG Li-li,PAN Zhi-fang,GENG Xiu-fang,LIU Hong-ying,LI Zhi-jian.(Weifang Medical University,Weifang 261041,Shandong Province,China);The effects of Ginkgo biloba leaf flavonoids and Quercetin on proliferation or Apoptosis of human liver cancer cell line HepG2[J];Chinese Journal of Birth Health & Heredity;2010-02
9 LI Guo-chen,HUI Qing-shan(Departmentof Neurosurgery,Anqiu Traditional Chinese Medicine Hospital,Anqiu,Shandong 262100,P.R.China);Research on influence of Ginkgo Biloba Extracts on proliferation and apoptosis of human glioblastoma U251 cells[J];China Medical Engineering;2013-05
10 Ye-Bo Mao;Shi-Quan Liu;Lin Tan;Qiao Zhou;Jie-An Huang;Department of Gastroenterology,the First Affiliated Hospital of Guangxi Medical University;;EGb761 enhances cisplatinand etoposide-induced apoptosis of human gastric cancer SGC-7901 cells[J];World Chinese Journal of Digestology;2013-31
Chinese Journal Full-text Database 7 Hits
1 Hou Dongyan *1,2 ,Hui Ruihua 1,2 , Mei Yang 2, Liu Xiaoyuan 3, Guan Chongxin 1 1(Department of Chemistry, Anshan Normal University , Anshan 114005) 2(Department of Chemistry, Liaoning Normal University, Dalian 116029) 3(Liaoning Longxing Biologe Science and Technology Co. Ltd., Anshan 114001);Determination of Total Flavonoids in Llex Kudincha by Three Wavelength Spectrophotometry[J];Chinese Journal of Analytical Chemistry;2004-06
2 HOU Dongyan*, Hui Ruihua, Li Tiechun(Department of Chemistry, Anshan Normal University, Aashan 114005), HOU Dongyan*, HUI Ruihua, YANG Mei(Department of Chemistry, Liaoning Normal University, Dalian, 116029), Xiaoyuan and ZHU Yongqiang (Liaoning Longxing Biologe Science and Technology Co. Ltd. Aashan 114001);Quantitative determination of total flavonoids in green tea by three wavelength spectrophotometry[J];Analytical Laboratory;2003-06
3 HUI Rui-hua, HOU Dong-yan, GUAN Chong-xin, LIU Xiao-yuanDepartment of Chemistry, Anshan Normal University, Anshan 114005, China;Quantitative Determination of Total Flavonoids in Sea-Buckthorn Fruit Juice by Three Wavelength Spectrophotometry[J];Spectroscopy and Spectral Analysis;2005-02
4 LIU Xin ping,XU Wen di (Department of Biochemistry and Molecular Biology,Harbin Medical University,Harbin 150086,China);Optimization of GBE extracting technology and effect of GBE on expression of Bcl-2 mRNA in Hela cell[J];Journal of Harbin Medical University;2005-03
5 PAN Hong-ping(People′s Hospital of Guangxi Autonomous Region, Nanning 530021, China);Progress in studies of pharmacological activities and clinical applications of preparations of dried leaf of Ginkgo biloba[J];China Journal of Chinese Materia Medica;2005-02
6 Huang Peili 1, Li Jianxin 2, Zhang Shuhua 1, Wang Hui 1 (1 Faculty of Public Health, Capital University of Medical Sciences, Beijing 100054; 2 Fu Wai Hospitial and CVD Institute of CAMS, Beijing 100037);Comparison Study on Inhibitory Effect of Extracts from Leaves of Ginkgo biloba L.on the Oxidation of Human Low Density Lipoproteins[J];Journal of Chinese Medicinal Materials;2004-09
7 ZHU Gui-yue, ZHU Xing-lei, GENG Qing-xin, e t al Department o f Cardiology, Shandong Provincial Hospital, Shandong University, Jinan(250021);Change of Peripheral Blood Monocytes Derived Macrophage Scavenger Recep tors Activi ty in Patients with Coronary Heart Disease, and the Intervention Effect of Gink go Biloba Extract[J];Chinese Journal of Integrated Traditional and Western Medicine;2004-12
Chinese Journal Full-text Database 10 Hits
1 KUANG Chun-tao et al (College of Material Science and Engineering,Central South University of Forestry and Technology,Changsha,Hunan 410004);Study on Extraction Process of Total Flavonoids from Pubescent Holly Root[J];Journal of Anhui Agricultural Sciences;2009-01
2 ZHANG Chao-bo,LI Chu-xi,LIU Meng,XU Lei (Nanjing Hailing R&D for Chinese Traditional Medicine Pharmaceutical Technology,Nanjing 210049);Pharmacodynamics research of Yinqu capsule on blood lipid regulating function[J];Anhui Medical and Pharmaceutical Journal;2011-04
3 HOU Dong-yan,HUI Rui-hua,LIU Xiao-yuan,YUAN Hua-fang (Department of Chemistry,Anshan Normal University,Anshan Liaoning 114007,China);Studies on Total Flavones and Anti-oxidation Effect of Black Teas[J];Journal of Anshan Normal University;2009-04
4 HUANG Xu-chu1,2,HOU Juan1,2,ZHANG Jian-jun1,2,LIU Yan1(1.Department of Physics,College of Teachers,Shihezi University,Shihezi 832003,China;2.Key Laboratory of Ecophysics,Shihezi University,Shihezi 832003,China);Extraction and Examination of Chlorogenic Acid from Flos Lonicerae by Microwave Pretreatment[J];Analysis and Testing Technology and Instruments;2008-01
5 LI Ming-jing1,ZHANG Wei1,ZHAO Dong-bao1,2 and LIU Xiu-hua1(1.College of Chemistry and Chemical Engineer,Henan University,Kaifeng 475001;2.Jiyuan Vocational and Technical College,Jiyuan 454650);Determination of the contents of total flavonoids in Artemisia ordosica by three wavelength spectrophotometry[J];Chinese Journal of Analysis Laboratory;2007-03
6 WANG Ke1,WANG Yong1,ZHAO Dong-bao1,3,LI Ming-jing1,LIU Xiu-hua1,2 and XU Ping-hui4(1.Environmental and Analytical Science Institute of College of Chemistry and Chemical Engineering,Henan University,Kaifeng 475004;2.Key Lab of Natural Drug and Immune Engineering,Henan Province,Kaifeng 475004;3.Jiyuan Vocational and Technical College,Jiyuan 454650;4.Xinxiang Biocaro biotech co.LTD,Xinxiang 453000);Determination of the contents of total flavonoids in lonicera japonica and its leaves by three wavelength spectrophotometry[J];Chinese Journal of Analysis Laboratory;2011-02
7 LI Na,MAO Yong-qiang(College of Science,Liaoning Engineering and Technology University,Fuxin,Liaoning 123000,China);Microwave Assisted Extraction Technology for Total Flavonoids from the Leaves of Llex kudincha[J];Guizhou Agricultural Sciences;2011-05
8 YANG Yu-juan☆,LI Guo-hao,LEI Xiu-xia,HE Guo-hua,MO Jian-min.☆Department of laboratory medicine,Yangcheng hospital,Guangzhou medical college,Guangzhou 510140,China;Effects of Ginkgo biloba extract on inflammation of HeLa cells[J];Guangdong Medical Journal;2012-04
9 WANG Xiu-li,LI Hai-yun(Department of Materials and Chemistry Engineering,Guilin University of Technology,Guilin 541004,China);Adsorptive ability for nitrite by water-insoluble dietary fibre from ginkgo shell[J];Journal of Guilin University of Technology;2006-04
10 WANG Xin1,ZHANG Lin-lin2(1.Department of Journal of Science of Teachers′College and University,Qiqihar University,Qiqihar 161006,China;2.No.4 Middle School of Qiqihar,Qiqihar 161005,China);Research of extract and application of sea buckthorn[J];Journal of Science of Teachers' College and University;2010-06
Chinese Journal Full-text Database 10 Hits
1 LI Rong, LI Jun (School of Pharmacy, Anhui Medical University , Hefei 230032,China);Advances in pharmacological research and structure-activity relationship of flavonoids[J];Anhui Medical and Pharmaceutical Journal;2005-07
2 ZHAO Ai-guang 1* ,YANG Jin-kun 1 ,ZHAO Hai-lei 1 ,LIU Li-kun 2 1.Department of Oncology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,P.R.China2.Shangxi Chinese Medicine Institu te,Taiyuan 030;Apoptosis Induction by Sijunzi Deco ction in Human Gastric Cancer Xenografts in Nude Mice[J];Chinese Journal of Cancer;2001-02
3 MA Jing1, FU Nai yang2, LI Yu mei3, PENG Wen lie1, XU An long1*1.Department of Biochemistry and Center for Biopharmaceutical Research, College of Life Science, Zhongshan University, Guangzhou 510275, P.R.China2.Institute for Drug Control of Guangdong;Glycyrrhiza uralensis Fisch Extract Selectively Induces Apoptosis in Several Human Cancer Cell Lines in Vitro[J];Chinese Journal of Cancer;2001-08
4 ZHANG Yi-Ying1, DENG Tao1, HU Zhi-Fang2, ZHANG Qiu-Ping2, ZHANG Jing1, JIANG Hua21. Department of Gastroenterology, People's Hospital,Wuhan University, Wuhan, Hubei, 430060, P. R. China2. Department of Immunology, Medical College, Wuhan University, Wuhan, Hubei, 430071, P. R. China;Mechanisms of Inhibiting Proliferation and Inducing Apoptosis of Human Gastric Cancer Cell Line SGC7901 by Ursolic Acid[J];Chinese Journal of Cancer;2006-04
5 Kamlesh Sodani,Atish Patel,Rishil J.Kathawala and Zhe-Sheng Chen Department of Pharmaceutical Sciences,College of Pharmacy and Allied Health Professions,St.John's University,Queens,NY 11439,USA.;Multidrug resistance associated proteins in multidrug resistance[J];Chinese Journal of Cancer;2012-02
6 ZHANG Ke1,WANG Ping1,ZHANG Qing2,YU Dong-hong1,CHEN Chang-jie3,CHENG Ze-nong1,LI Bai-qing4(1.Department of Pathology,The First Affiliated Hospital of Bengbu Medical College,Department of Pathology,Bengbu Medical College,Bengbu Anhui 233030;2.Central Laboratory,Affiliated Hospital of Bengbu Medical College,Bengbu Anhui,233004;3.Department of Biochemistry and Molecular Biology;Bengbu Medical College,Bengbu Anhui,4.Anhui Key Laboratory of Infection and Immunology,Benbu Anhui 233030,China);Influence of quercetin on proliferation of gastric cancer line BGC 823 and the expression of caspase-3,Bcl-2[J];Journal of Bengbu Medical College;2009-05
7 HE Hai Yan YANG Dong Ni QIAN Cheng YUAN Hong Sheng SUN Jiu Rong (College of Lifescience, Peking University, Beijing 100871, China);EFFECTS OF FLAVONOID OF GINKGO BILOBA ON THE FUNCTIONAL CHANGES FOLLOWING BRAIN INJURY IN RATS[J];Acta Zoologica Sinica;2002-02
8 Chen LiangLiang,Wu Liangcun, Li Qingxia,et al Zhejiang provincial Hospital of TCM,Hangzhou(310006);Experimental Study of Danshen Injection on TILS' Expansion in Vitro and Cytotoxicity[J];Journal of Zhejiang College of Tcm;2002-03
9 JIANG Wei1,XU Cong-jian1,2,CONG Qing1,WANG Yi-sheng1,SUN Xia2,BIN Ye3 (1Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200011,China;2Institute of Biomedical Sciences,Fudan University,Shanghai 200032,China;3Brigham and Women's Hospital,Harvard Medical School,USA);Research on Ginkgolide B increases Cisplatin sensitivity in ovarian cancer cell via down-regulation of excision repair cross-complementing 1(ERCC1) in vitro[J];China Journal of Traditional Chinese Medicine and Pharmacy;2012-03
10 ZHANG Li-jiao1,TONG Ju-hui2,GAO Li-hong1,FEI Rui2,YANG Yang1 (1.School of Life Science,Changchun Normal University,Changchun 130032,China;2.Department of Norman Bethune Medical Science,Jilin University,Changchun 130021,China);The Effects of Polysaccharides from Ginkgo Biloba Leave on Proliferation of Human Melanoma Cell[J];Journal of Changchun Normal University(Natural Sciences);2008-12
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 JIN Dang-qin(Yangzhou Institute of Industrial Technology,Yangzhou 225127);Determination of ginkgolic acids in the epicarp of ginkgo biloba by supercritical CO_2 extraction-HPLC[J];Chinese Journal of Analysis Laboratory;2013-06
2 DI Jianxin1,WANG Jie2 1 Minqin County People′s Hospital,Minqin 733300,China; 2 Basic Medical School of Lanzhou University;Experimental Study of Spriulina Polysacchrides on the Proliferation and Apoptosis Rate of Hepatoma Carcinoma Cells Induced by Radiation[J];Western Journal of Traditional Chinese Medicine;2013-07
3 CAO Song-yi,GUO Wei,ZHANG Shao-bin,LIU Hui(College of Biological Science and Technology,Shenyang Agricultural University,Shenyang 110161,China);Research Progress on the Factors Influencing the Content of Polysaccharide of Spirulina[J];Journal of Hebei Agricultural Sciences;2010-05
4 Liu Yan,Jiang Shi-hong Henan University of Chinese Medicine,Zhengzhou,Henan,China 450008;Progression of In Vitro Experimental Study on Gastric Cancer Cell Strains Treated by Prescriptions Made of Chinese Herbs[J];China Journal of Chinese Medicine;2011-08
5 LI Zuan-fang,CHEN Wen-lie,CHEN Rong.Electron Microscopic Laboratory,Fujian Academy of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350108,China;Application of laser scanning confocal microscopy on research of tumor cell apoptosis inducted by traditional Chinese medicines and natural medicines[J];Global Traditional Chinese Medicine;2011-01
6 XU Ping,SUN Jing,HU Wen-jing,YU Li-xia,QIAN Xiao-ping,LIU Bao-rui(Department of Oncology,Drum Tower Clinical College of Nanjing Medical University & Clinical Cancer Institute of Nanjing University,Nanjing 210008,Jiangsu,China);Ethanol extract of Fructus Forsythiae inhibits proliferation and induces apoptosis of human gastric cell line BGC-823[J];Journal of Medical Postgraduates;2007-12
7 SUN Zhen1,WANG Zhong1,YU Zheng-hong2 reviewing,LING Chang-quan3 checking(1.Department of Sanitarium Area,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 211131,Jiangsu,China;2.Department of Oncology,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China;3.Department of Traditional Chinese Medicine,Changhai Hospital,Second Military Medical University,Shanghai 200433,China);Research in progress of compound Chinese medicine preparations on preventing the hepatocellular carcinoma[J];Journal of Medical Postgraduates;2011-05
8 PAN Hongmei,WU Caie*,CAO Fuliang,FAN Gongjian,YANG Jianting,JIA Shaoqian,LI Tingting(College of Forest Resources and Environment,Nanjing Forestry University,Nanjing 210037,China);Study on extraction and compositions of ginkgolic acids in ginkgo seeds[J];Journal of Nanjing Forestry University(Natural Sciences Edition);2011-06
9 WANG Xin-xing1,ZHANG Luo1,SUN Zhen2 reviewing,YU Zheng-hong1 checking(1.Department of Oncology,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 210002,Jiangsu,China;2.Tangshan Sanitarium,Nanjing General Hospital of Nanjing Military Command,PLA,Nanjing 211131,Jiangsu,China);Evil-expelling Chinese drugs for primary hepatic carcinoma[J];Journal of Medical Postgraduates;2012-12
10 JIN Dang-qin;Yangzhou Polytechnic Institute;;Biological Activity and Control Effect of Ginkgolic Acids on Spodoptera exigua (Hübner)[J];Journal of Henan Agricultural Sciences;2013-09
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Sun Jianxin;Gu Hong;Wang hui(Department of Science and Research, Second MilitaryMedical University,Shanghai,200433);Effect of ginkgo biloba L extract on energy metabolism of ischemic brain in mice[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1995-06
2 Li Meiqing 1, Sheng Xuan 2, Shao Xueguang *1 1(Department of Chemistry, University of Science and Technology of China, Hefei 230026) 2(Anhui Entry-Exit Inspection and Quarantine Bureau, Hefei 230061);Separation and Determination of Active Components of Pueraria Lobata Isoflavonoid Extract by Reversed Phase High Performance Liquid Chromatography[J];Chinese Journal of Analytical Chemistry;2003-02
3 DING Ming yu,LI Qing yang (Department of Chemistry, Tsinghua University, Beijing 100084) and ZHAO Ji ping (Institute of Chemical Defence, Beijing 102205);Study on determination methods of total flavonoids in the extractive of hypericum perforatum L[J];Analytical Laboratory;2001-06
5 Chen Youdi Jiang Zirong Qin Wenlong Ni Manna Li Xiuling He Youren (Research Institute of Chemical Processing and Utilization of Forest Products, Chinese Academy of Forestry Nanjing 210037 );CHEMICAL COMPOSITION AND CHARACTERISTICS OF SEABUCKTHORN FRUIT AND ITS OIL[J];Chemistry & Industry of Forest Products;1990-03
6 Hu Min(49);Study on optimum extraction process of flavonoids from Ginkgo biloba L[J];SCIENCE AND TECHNOLOGY OF FOOD INDUSTRY;1997-05
7 YangYang et al;Study on Extraction Technology of Flavonoid from Pomelo Peel[J];Food Science;2001-03
8 Ding LiJun et al.;Extraction studies on the Flavonoid fromHoneysuckle[J];Food Science;2002-02
9 Du Wei;Determination of Content of Total Flavonoids in Cili and Resources Development Prospect[J];Food Science;2003-01
10 Zhao Huichun,Feng Ruiqin,Fang Xin (Department of Chemistry,Beijing Normal University, Beijing, 100875);Fluorimetric Determination of Puerarin in “Yufongninxin”Tablets[J];JOURNAL OF INSTRUMENTAL ANALYSIS;1997-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved