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《World Chinese Journal of Digestology》 2005-21
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Inhibitory effects of Ginkgo biloba leaf flavonoids on proliferation of human gastric cancer cell line BGC823 in vitro

Feng Zhang, Gui-Wen Yang, Jin-Feng Zhang, Li-Guo An, Key Laboratory of Animal Resistance, College of Life Sciences, Shandong Normal University, Jinan 250014, Shandong Province, China  
AIM: To extract the avonoids from Ginkgo biloba leaf, and to investigate its inhibitroy effects on the prolifera- tion of human gastric cancer cell line BGC823 cultured in vitro. METHODS: Ethanol (700 mL/L) was used to extract the flavonoids from the leaf of Ginkgo biloba. Three wavelength spectrophotometry was used to determine the content of avonoids in the extracts. Human gastric cancer cells BGC823 cultured in vitro were treated with different concentrations of the avonoids, and then the proliferation of the cells was detected by MTT assay and ow cytometry. RESULTS: The content of flavonoids in the extracts was 140 mg/g. The avonoids from Ginkgo biloba leaf inhibited the proliferation of BGC823 cells in a dose- dependent manner. The rate of cells in S phase was notably increased as compared with that in the controls (42.17±0.50% vs 32.13±0.45%, P = 0.001), and the ap- optotic rate of the cells was also increased (4.10±0.03% vs 2.21±0.01%, P = 0.002). CONCLUSION: Ginkgo biloba leaf avonoids can in- hibit the proliferation of human gastric cancer cell line BGC823 by affecting the cycle the cells.
【CateGory Index】: R735.2
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