Investigation on the risks of colorectal cancer in patients with diabetes mellitus
Shui-Qing Hu, Zhe Tang, Mei Zhang, Department of Gastroenterology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China
AIM: To investigate the influences of DM- associated factors on the pathogenesis of colorectal cancer (CRC), and clarify whether diabetes mellitus (DM) is a risk factor of CRC. METHODS: A case-control study was per- formed to compare 364 colorectal cancer patients (198 colon cancer patients and 166 rectal cancer patients) with 733 controls (patients without cancer), with respect to their family history of CRC and DM, personal DM history, habits of smoking and drinking, cholesterol and triglycer- ide levels. RESULTS: The value of odds ratio (OR) in patients with DM history was 1.72 and that in patients with family DM history was 1.64. The value of OR in DM patients with family CRC history was 3.23, significantly higher in DM pa- tients without family CRC history (OR = 1.57). After further analysis, the rate of DM patients with/without family CRC history was always higher than that in the controls. Logistic analy- sis showed that the age, gender, DM history, coronary heart disease, hypertension, smoking, drinking, and blood lipid had no marked re-lationship with colorectal cancer, but DM and family CRC history were correlated with the oc- currence of colorectal cancer (OR = 2.99, P 0.01; OR = 1.79, P 0.01). CONCLUSION: DM is an independent risk fac- tor of CRC. Routine examination for CRC is recommended for DM patients to make earlier diagnosis of CRC and improve the prognosis of patients.
【CateGory Index】： R587.1;R735.3