Relationship between pancreatic acinar cell apoptosis and acute pancreatitis and the therapeutic strategy for acute pancreatitis
Gui-Xin Zhang, Hai-Long Chen, Department of Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China Ai-Xia Gong, Department of Gastroenterology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China Li Zhang, Center Laboratory, Dalian Municipal Central Hospital, Dalian 116033, Liaoning Province, China
Being a kind of automatic and gene-controlled cell death, cell apoptosis involves complicated regulatory mechanism and stimulates no inflammation, which is essentially different from necrosis. Many researches proved that the apoptosis of pancreatic acinal cells, which might be a protective reaction, had been observed both in experimental and clinical acute pancreatitis, and it had shown an inverse correlation with the severity of diseases. The purpose of this article is to summarize the advances in the mechanism of pancreatic acinar cell apoptosis during acute pancreatitis in recent years, and to expound the therapeutic approaches in the treatment of acute pancreatitis.