NK cell activation and immune response in inflammatory bowel disease
Min-Qiang Shen, Zhan-Ju Liu, Department of Gastroen-terology, the Second Affiliated Hospital of Zhengzhou Uni-versity, Zhengzhou 450014, Henan Province, ChinaMin-Qiang Shen, Department of Gastroenterologey, the 152th Hospital of Chinese PLA, Pingdingshan 467000, Henan Province, China
Inflammatory bowel disease (IBD) is closely associated with the abnormal immune response of intestinal immune system to enterobacteria and dietary antigens. Large amounts of mononuclear lymphocyte infiltrates and high expression levels of proinflammatory cytokines and costimulatory molecules are present in inflamed mucosa. NK cells, involved in innate and acquired immune response, have cytolitic activities through secretion of lytic proteins, and produce proinflammatory mediators. Increased infiltration of NK cells present in inflamed mucosa of IBD expresses high levels of activated molecules and proinflammatory cytokines, and plays a role in intestinal mucosal damage.