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《World Chinese Journal of Digestology》 2008-32
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Hepatic ischemia reperfusion injury and calcium overload

Yuan-Yuan Yue, Zhi-Jie Feng, Department of Gastroenterology, the Second Hospital Affiliated to Hebei Medical University, Shijiazhuang 050000, Hebei Province, China  
Hepatic ischemia reperfusion injury is a common pathophysiologic process, whose basic mechanism is related to intracellular calcium overload. Calcium overload is related to cell membrane cranny, Na+/Ca2+ exchanger, the decreased activity of Ca2+-ATPase, mitochondrial dysfuncsion and oxygen free radicals. The prophylaxis and treatment options of calcium overload include: ATP-sensitive K+ channel openers, anesthesia, calcium channel entry blockers, mitochondrial permeability transition inhibitors, heme oxygenase 1 and so on.
【CateGory Index】: R575
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