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《World Chinese Journal of Digestology》 2009-05
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Effects of curcumin solid dispersion on oxidative stress of alcoholic hepatic injury in rats

Gang Han, Hai-Zhong Yuan, Yue Dong, Pharmaceutical Science, North China Coal Medical University, Tangshan 063000, Hebei Province, China Guo-Xian Yao, Department of Pharmacy, Fengrun People’s Hospital Tangshan 064000, Hebei Province, China  
AIM: To prepare curcumin solid dispersion and to investigate the effects of curcumin solid dispersion on oxidative stress of alcoholic hepatic injury in rats. METHODS: Fifty Sprague-Dawley rats were randomly divided into 5 groups (n = 10): control group, model group, Bifendate group and two curcumin solid dispersion treatment (100, 200 mg/kg, respectively) groups. The SD rats were administrated with liquor and fat emulsion for 6 weeks to establish the alcoholic hepatic injury model, at the same time the rats were administrated Bifendate and curcumin solid dispersion. The content of alanine aminotransferase (ALT), asparate aminotransferase (AST) in serum and the activity or content of superoxide dismutase(SOD) and malondialdehtyde (MDA) in liver were measured to evaluate hepatic injury and oxidative stress. RESULTS: Compared with control group, the value of liver weight/body weight was signifi - cantly increased (3.74 ± 0.38 vs 2.25 ± 0.13; P 0.01); the serum ALT and AST were signifi cantly increased (76.24 ± 9.14 vs 30.13 ± 4.99; 98.85 ± 10.50 vs 39.02 ± 6.79; P 0.01) but the activity of SOD was signif icantly decreased (395.39 ± 28.26 vs 258.18 ± 22.18, P 0.01) and the content of MDA was signif icantly increased (27.00 ± 1.08 vs 12.31 ± 1.26, P 0.01) in the model group. How- ever, in comparison with those in model group, the serum AST and ALT were significantly decreased (Bifendate 29.01 ± 9.24, 41.69 ± 3.67; Low dose 55.92 ± 5.49, 57.17 ± 10.88; High dose 40.94 ± 4.54, 52.59 ± 10.17) in the two treatment groups. For low dose and high dose curcumin solid dispersion groups, activity of SOD was signifi cantly increased (Low dose 340.50 ± 36.26, High dose 365.20 ± 36.18, P 0.01) and content of MDA was signifi cantly decreased (Low dose 15.76 ± 0.68, High dose 13.19 ± 0.72, P 0.01) in liver, but there was no signif icant change in Bifendate group. CONCLUSION: The curcumin solid dispersion protects alcoholic hepatic injury and reduces oxidative stress in rats.
【Fund】: 中国煤矿尘肺治疗基金资助项目 No.2006-11~~
【CateGory Index】: R285.5
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