Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《World Chinese Journal of Digestology》 2009-08
Add to Favorite Get Latest Update

Effects of salidroside on expression of ROCK in rats with liver fibrosis

Xiao-Ling Wu,Wei-Zheng Zeng,Ming-De Jiang,Jian-Ping Qin,Hui Xu,Zhao Wang,Department of Gastroenterology,General Hospital of Chinese PLA,Chengdu Military Command,Chengdu 610083,Sichuan Province,China  
AIM:To observe the effects of salidroside on the expression of ROCK in liver tissue of CCl4-induced liver fibrosis in rats,and to explore its probable mechanism.METHODS:Ninety healthy SD rats were ran-domly divided into 3 groups:control group (n = 10),salidroside group (n = 40) and liver fi brosis group (n = 40). Experimental liver fi brosis was induced by (with the concentration of 300 mL/L soluted in liquid paraffin) subcutaneous injection of CCl4 (at the dosage of 3 mL/kg,twice per wk,8 wks). The salidroside was injected into the peritoneal cavity at the dosage of 5 mg/kg,twice per week for 8 weeks. Liver tissues from each group were stained with Masson and HEstaining to observe the collagen deposition. Expressions of ROCKⅠand ROCKⅡ in the liver tissue were detected with in situ hybridization (ISH) and immunohistochemistry (IH) respec-tively. All the figures were scanned with elec-tronic computer,and the data were analyzed with Image-Plus software.RESULTS:A signif icant collagen deposition and rearrangement of the parenchyma were noted in liver tissue of CCl4-treated rats. There were lots of pseudolobule in liver tissue. The semi-quantitative histological scores and average area of collagen were significantly increased when compared with control rats (2.1 ± 0.3 vs 3.6 ± 0.8,74.82 ± 21.51 μm2 vs 290.86 ± 89.37 μm2,both P 0.05). Compared with control group,the expressions of ROCKⅠ,ROCKⅡ and ROCKⅠmRNA,ROCKⅡmRNA were decreased significantly in salidroside group (0.203 ± 0.068 vs 0.357 ± 0.182,0.237 ± 0.056 vs 0.394 ± 0.238; 0.197 ± 0.019 vs 0.394 ± 0.238,0.185 ± 0.031 vs 0.279 ± 0.112,P 0.05 or 0.01).CONCLUSION:The expressions of ROCKⅠand ROCKⅡ in liver tissues are inhibited significantly with salidroside treatment. Salidroside could interfere with the signal transduction of Rho-ROCK pathway and then inhibit liver fibrosis in rats.
【Fund】: 四川省科技厅应用基础研究科研基金资助项目 No.05JY029-015~~
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 1 Hits
1 Hua-Zhang,Department of Gastroenterology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China Wei-Zheng Zeng,Xiao-Ling Wu,Department of Gastroenterology,General Hospital of Chengdu Military Command of Chinese PLA,Chengdu 610083,Sichuan Province,China;Protective effects of Rhodiola sachalinensis A.Bor on liver fibrosis:recent advances[J];World Chinese Journal of Digestology;2010-25
Chinese Journal Full-text Database 10 Hits
1 ZHANG Xiao-lan1, LI Xu2, XIAO Bing1, HUANG Mao-liang1, MENG Ying3, LI Ying-fei1, WANG Yuan-yuan1, SONG Wei-bing1 1Department of Digestive Diseases, 2Department of Emergency Medicine, 3Department of Respiratory Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Effect of angiotensin II on Rho-Rock pathway in rat hepatic stellate cell contraction[J];Journal of Southern Medical University;2008-06
2 LU Li-fang, HU Ji-an. (Dept. of Pathology, Affiliated Hospital of Stomatology, College of Medicine, Zhejiang University, Hangzhou 310006, China);Association between RhoC and salivary gland tumor[J];International Journal of Stomatology;2008-02
3 ;Rho-ROCK signaling system[J];Progress in Japanese Medicine;2007-01
4 SUN Jun-ping,ZHANG Juan,SONG Zhao-feng,LI Xiao-xing,JI Xiao-ping (Department of Cardiology,Qilu Hospital of Shandong University,Key Laboratory of Cardiovascular Remodeling and Function Research,Chinese Ministry of Education and Public Health,Jinan 250012,China);Effects of Rho-kinase on cardiac apoptosis induced by ischemia/reperfusion injury in neonatal rat cardiomyocytes[J];Journal of Shandong University(Health Sciences);2008-05
5 LI Ning LI Li-juan ZHANG Xiao-bo YAO Hai-tao Department of pathology,School of Basic Medical Sciences,Jiamusi University,154007,Jiamusi,China TANG Jin-tian WANG Xiao-wen Department of Engineering Physics,tsinghua University,Beijing,100084,China;Effects of Rho kinase on invasion and immigration of in vitro colorectal cancer cell[J];Progress in Modern Biomedicine;2008-07
6 Wei-Zheng Zeng, Ming-De Jiang, Department of Gastroenterology, General Hospital of Chengdu Command, Chengdu 610083, Sichuan Province, China Xiao-Ling Wu, Pi-Long Wang, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China Gui-Zhen Chu, West China Center of Medical Sciences, Sichuan University, Chengdu 610054, Sichuan Province, China Supported by Medical Science Foundation of Chengdu Command in the 10th Five Year Plan, No.01A009;Effect of Salidroside on gene expression of CBP and Smad in CCI_4-induced liver fibrosis in rats[J];World Chinese Journal of Digestology;2005-03
7 Na Liu Xiao-Lan Zhang Department of Gastroenterology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,Hebei Province,China;Gene therapy for hepatic fibrosis[J];World Chinese Journal of Digestology;2008-03
8 Xiao-Ling Wu, Wei-Zheng Zeng, Ming-De Jiang, Jian- Ping Qin, Hui Xu, Department of Gastroenterology, Gen- eral Hospital of Chinese PLA Chengdu Command, Chengdu 610083, Sichuan Province, China;Expression of Smads gene in CCl_4-induced liver ?brosis and its signi?cance in rats[J];World Chinese Journal of Digestology;2008-10
9 Dong-Pu Liu, Feng-Mei Lu, Chun-Bin Zhang, Department of Pathology, Basic Medical College of Jiamusi University, Jiamusi 154007, Heilongjiang Province, China;Effect of Chinese herbs compound Rhodiola sachalinensis on the expression of tissue inhibitor of metalloproteinase1 in fibrotic fiver in rats[J];World Chinese Journal of Digestology;2008-31
10 CHU Yu-feng, CHEN Wen-dong, ZHU Ding-liang, GAO Ping-Jin. Ruijin Hospital Shanghai Key Laboratory of Vascular Biology and Laboratory of Vascular Biology of Health Science Center, Shanghai JiaoTong University School of Medicine. Shanghai Institute of Hypertension. State key Laboratory of Medical Genomics, China;RhoA/ROCK Signaling Pathway is Involved in Phenotypic Differentiation of Adventitial Fibroblasts Induced by Angiotensin Ⅱ[J];Chinese Journal of Hypertension;2007-06
Chinese Journal Full-text Database 10 Hits
1 YING Song-song1, LI Xu2, HUANG Mao-liang1, MENG Ying3, ZHANG Zhen-shu1 1Department of Digestive Diseases, 2Department of Emergency Medicine, 3Department of Respiratory Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Effect of angiotensin1-7 on α-smooth muscle actin protein expression in rat hepatic stellate cells[J];Journal of Southern Medical University;2009-04
2 JIANG Ming,XIONG Wu-jun,LIU Fei.Department of Gastroenterology,Shanghai East Hospital,Tongji University,Shanghai 200120,China;Wnt signal pathway and anti-fibrosis strategy[J];International Journal of Internal Medicine;2009-04
3 XU Li-bao1,WANG Tian-xiao2,SUN Wei1,YANG Xiao-hong1,ZHOU Xiao-ping1,XU Yan1(1.School of Pharmacy,Jilin University,Changchun 130021,China;2.Institute of Pharmacy,Henan University,Kaifeng 475004,China);Rho kinase inhibitors:a research progress[J];Journal of International Pharmaceutical Research;2008-06
4 ZHANG Bao-Fang,CHENG Ming-Liang*,WANG Yu-Ping,MU Mao Department of Infectious Diseases,Guiyang Medical College Affiliated Hospital,Guiyang 550004,China;Influence of blueberry on TGF-β_1/Smads signal transduction in liver tissues of the rats with liver fibrosis[J];Infectious Disease Information;2010-03
5 Gao Yan1, Xie Min1, Shi Junqing2 (1Department of Respiratory Diseases, West China Hospital, Sichuan University; 2Department of Respiratory Diseases, First People’s Hospital of Chengdu, Chengdu, Sichuan Province, 610041, China);Fasudil attenuates hypoxia-induced pulmonary fibrosis via suppressing Rho/Rock signal pathway[J];Acta Academiae Medicinae Militaris Tertiae;2010-22
6 ;Research advance on pharmacological action of salidroside[J];Journal of Jilin Medical College;2007-03
7 LIU Yong-Zhi, WEI Jia, ZHANG, ZHANG Peng (1.Department of Central Surgery, the First Afflicated Hospital ;2.Department of Cental Laboratory; 3. Department of Assessment Liaoning Medical University, Liaoning Jinzhou 121001 China);The Effect of RhoGTPase on Breast Cancer[J];Progress of Anatomical Sciences;2007-02
8 YANG Xiao,DENG Bingqing,ZHU Zhonghua,et al Department of Nephrology,Union Hospital,Tongji Medical College,Hua-zhong University of Science and Tachnology,Wuhan(430022);Inhibitition of Rho-kinase Retards the Daunorubicin Induced Progressive Glomerulosclerosis[J];Chinese Journal of Integrated Traditional and Western Nephrology;2008-05
9 Nie Fugen,Yu Hua,Zhang Yanglong(1Department of cardiology,the first affiliated hospital of NanChang university,330006;2 The affiliated hospital of JiuJiang college,JiuJiang,332000,China);Effects of fasudil on the development of left ventricular remodeling in rats with pressure overload[J];Jiangxi Medical Journal;2008-06
10 DENG Zhi-Kuan, CHENG Xiao- Yan, WANG Ruo-Dan, JIANG Li-Ping, HUANG Hua Departmant of Neurology, the Second Affiliated Hospital, the Third Military Medical University, Chongqing 400037, China;Clinical Efficacy of Fasudil in Treatment of Acute Ischemic Stroke[J];Chinese Journal of Clinical Neurosciences;2007-05
Chinese Journal Full-text Database 10 Hits
1 Zhao Zonghao, Mei Qiao, Wu Jun, et al First Affiliated Hospital of Anhui Medical College,Hefei 230022;Role of NF-κB in rat liver fibrisis[J];Anhui Medical Journal;2003-05
2 SONG Xiang-fu 1, ZHANG Jing-chun 2, WU Xiao-hui 1 (1. Department of Laboratory Animal, School of Pbulic Health, Jilin University, Changchun 130021,China;2. Department of Laboratory,China-Japan Union Hospital, Jilin University,Changchun 130031, China);Effects of Rhodiola extracts on lipideperoxygen and apoptosis of hepatocytes in aged mice[J];Journal of Jilin University of (Medicine Edition);2004-05
3 YAN Mao-xiang,CHEN Zhi-yun,HE Bei-hui(Laboratory of Digestive Disease,Zhejiang Hospital of Traditional Chinese Medicine,Hangzhou 310006,China);Effect of total flavonoids of Chinese hawthorn leaf on expression of NF-κB and its inhibitor in rat liver with non-alcoholic steato-hepatitis[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-02
4 ZHANG Guo-Zhen, WU Xiao-Chuan, PENG Xiao-Jie, YI Zhu-Wen, MO Shuan-Hong, TAN Hang. Laboratory of Pediatric Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China;Effects of astragalus on renal tubulointerestitial lesions and expression of NF-κB and MCP-1 in renal tissues in rat experimental IgA nephropathy[J];Chinese Journal of Contemporary Pediatrics;2008-02
5 ZHANG Gui-ling1,SHI Xiao-feng2,RAN Chang-qing3,XU Man4,ZHU Zhao-jing4(1Department of Infectious Diseases,Yuyao People's Hospital,Yuyao 315400;2Department of Infectious Diseases,Key Laboratory of Molecular Biology on Infection Diseases,Ministry of Education,The Second Affiliated Hospital,Chongqing 400010,4College of Basic Medicine,Chongqing Medical University,Chongqing 400016;3Institute of Chongqing Chinese Traditional Medicine,Chongqing 400065,China);Effects of total saponins of panax notoginseng against liver fibrosis in rats[J];Acta Academiae Medicinae Militaris Tertiae;2007-23
6 WU Xiao-Ling1,ZENG Wei-Zheng2,JIANG Ming-De2,WANG Pi-Long1,DENG Gui-Ying3,QIN Jian- Ping2 1Department of Gastroenterology,First Affiliated Hospital of Chongqing University of Medical Sciences,Chongqing 400016,China,2Department of Gastroenterology,General Hospital of Chengdu Military Command,Chengdu 610083,China,3Department of Gastroscope,Sixth Hospital of Chengdu City,Chengdu 610051,China;Effects of salidroside on expression of Smads gene in rats with hepatic fibrosis[J];Journal of The Fourth Military Medical University;2005-10
7 LIU Dong-pu,ZHAO Zhen-fu,LU feng-mei,ZHANG Hui,ZHANG Chun-bin.Department of Pathology,Basic Medical College,Jiamusi University,Jiamusi 154007 China;Effect of Rhodiola Sachalinensis in preventing hepatic fibrosis[J];Anatomy Research;2008-05
8 Zhen Zhen*,Song Huijuan,Li Wujun,Zhao Caiyan,Zhou Junyin(Department of Infectious Disease,The Third Hospital,Hebei Medical University,Shijiazhuang 050051,China);EXPRESSION AND SIGNIFICANCE OF NF-κB AND TNF-α IN LIVER TISSUE OF FULMINANT HEPATIC FAILURE[J];Chinese Journal of Histochemistry and Cytochemistry;2008-01
9 SONG Jin-ye,LI Shen,MENG Li-qiang,QU Lei,LI Xiao-mei(Department of Renal Division,Peking University First Hospital;Institute of Nephrology,Peking University;Key Lab of Renal Diseases,Ministry of Health of China,Beijing 100034,China);Renoprotective effects of astragalus and angelica mixture in rats with 5/6 nephrectomy[J];Journal of Peking University(Health Sciences);2009-02
10 SONG Yan,DING Guohua,GUI Yuan,HUANG JinpingDetp.of Nephrology,Renmin Hospital of Wuhan University,Wuhan 430060,China;Effects of Astragalus on the Expression of TLR4 in Rat Kidney with Acute Pyelonephritis[J];Medical Journal of Wuhan University;2006-05
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 LIANG Zhi qing,XU Xin bao,He Zhen ping. (Department of Obstetrics and Gynecology,Southwest Hospital,the Third Military Medical University,Chongqing 400038,China);Regulated expression of the MMPs and TIMPs in rat liver fibrosis by antisense Smad4 gene[J];Chongqing Medical Journal;2004-05
2 DENG Xin1,LIANG Jian1,HUANG Bin1,LI Yi-zhong1,QIN Li-kui1,ZHANG Xi-liu2(1.The Affiliated Ruikang Hospital of Guangxi Traditional Chinese Medical College,Nanning 530011,China;2.The First Affiliated Hospital of Guangxi Traditional Chinese Medical College,Nanning 530011,China);Effects of natural taurine on TGF-β_1/Smad singaling pathway in rats of hepatic fibrosis[J];Journal of Dalian Medical University;2007-04
3 SHEN Bo,YANG Da-ming,MENG Xian-yong.Department of Gastroenterology,Affiliated Hospital of Nantong University,Nantong 226001,China;Intracellular signal transduction in the hepatic stellate cell during liver fibrosis[J];International Journal of Internal Medicine;2007-08
4 CHEN Chen,YE Dongmei,SHAO ShujuanDepartment of Histology and Embryology,Dalian Medical University,Dalian,Liaoning,116027,China;Advances in the Research of TGF-β/Smad Signal Transduction[J];Journal of Medical Molecular Biology;2006-02
5 RUAN Yi-hua,LIU Hai-lin. Department of Gastroenterology,The Ninth People's Hospital, Affiliated to School of Medicine, Shanghai Jiao Tong University, Shanghai(200011),China;Smad7 and liver fibrosis[J];International Journal of Digestive Diseases;2007-03
6 HU Jun-jie,LI Ding-guo.Department of Gastroenterology,Xinhua Hospital,Medical School Affiliated by Shanghai Jiaotong University,Shanghai(200092),China;Research progress of TGF-β receptors in liver fibrosis[J];International Journal of Digestive Diseases;2007-04
7 WANG Yu_qin, LI Ding_guo, ZHOU Xin, et al (Department of Gastroentorology, Xinhua Hospital, SSMU, Shanghai 200092, China);Effects of Different Doses of Angiotensin Ⅱ on Proliferation and Intracellular Free Calcium Content of Rat Hepatic Stellate Cells[J];Acta Universitatis Medicinalis Secondae Shanghai;2002-04
8 Lin Shouning1,Wang Zhenchang2,He Lei3,Wei Gang3,Zheng Shenhong3 1.Department of Gastroenterology,Ruikang Hospital Affiliated to Guangxi College of Traditional Chinese Medicine,Nanning,Guangxi 530011 2.First Hospital Affiliated to Guangxi College of Traditional Chinese Medicine,Nanning,Guangxi 530023 3.Guangxi College of Traditional Chinese Medicine,Nanning,Guangxi 530001;Effect of Zhuanggan Zhuyu Granules on TβRⅠ/Ⅱ,Smad3,Smad4 and Smad7 Expression in Hepatic Fibrosis of Rats[J];World Journal of Integrated Traditional and Western Medicine;2007-10
9 ZHOU Shuping,WANG Qingming,WU Zuze(Beijing Institute of Radiation Medicine,Beijing100850,China);Gene therapy progress of cytokines in hepatic fibrosis[J];Chinese Bulletin of Life Sciences;2007-04
10 Yang Jun Si Shuyi Zhang Yueqin (Chinese Academy of Medical Sciences Institute of Medicinal Biotechnology Beijing 100050);TGF-β Superfamily Signaling Pathway[J];Progress In Biotechnology;2003-12
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved