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《World Chinese Journal of Digestology》 2009-08
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Effects of salidroside on expression of ROCK in rats with liver fibrosis

Xiao-Ling Wu,Wei-Zheng Zeng,Ming-De Jiang,Jian-Ping Qin,Hui Xu,Zhao Wang,Department of Gastroenterology,General Hospital of Chinese PLA,Chengdu Military Command,Chengdu 610083,Sichuan Province,China  
AIM:To observe the effects of salidroside on the expression of ROCK in liver tissue of CCl4-induced liver fibrosis in rats,and to explore its probable mechanism.METHODS:Ninety healthy SD rats were ran-domly divided into 3 groups:control group (n = 10),salidroside group (n = 40) and liver fi brosis group (n = 40). Experimental liver fi brosis was induced by (with the concentration of 300 mL/L soluted in liquid paraffin) subcutaneous injection of CCl4 (at the dosage of 3 mL/kg,twice per wk,8 wks). The salidroside was injected into the peritoneal cavity at the dosage of 5 mg/kg,twice per week for 8 weeks. Liver tissues from each group were stained with Masson and HEstaining to observe the collagen deposition. Expressions of ROCKⅠand ROCKⅡ in the liver tissue were detected with in situ hybridization (ISH) and immunohistochemistry (IH) respec-tively. All the figures were scanned with elec-tronic computer,and the data were analyzed with Image-Plus software.RESULTS:A signif icant collagen deposition and rearrangement of the parenchyma were noted in liver tissue of CCl4-treated rats. There were lots of pseudolobule in liver tissue. The semi-quantitative histological scores and average area of collagen were significantly increased when compared with control rats (2.1 ± 0.3 vs 3.6 ± 0.8,74.82 ± 21.51 μm2 vs 290.86 ± 89.37 μm2,both P 0.05). Compared with control group,the expressions of ROCKⅠ,ROCKⅡ and ROCKⅠmRNA,ROCKⅡmRNA were decreased significantly in salidroside group (0.203 ± 0.068 vs 0.357 ± 0.182,0.237 ± 0.056 vs 0.394 ± 0.238; 0.197 ± 0.019 vs 0.394 ± 0.238,0.185 ± 0.031 vs 0.279 ± 0.112,P 0.05 or 0.01).CONCLUSION:The expressions of ROCKⅠand ROCKⅡ in liver tissues are inhibited significantly with salidroside treatment. Salidroside could interfere with the signal transduction of Rho-ROCK pathway and then inhibit liver fibrosis in rats.
【Fund】: 四川省科技厅应用基础研究科研基金资助项目 No.05JY029-015~~
【CateGory Index】: R285.5
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