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《World Chinese Journal of Digestology》 2010-28
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Aloe improves gastric ulcer in pylorus-ligated rats

Bi-Lan Huang,Liang-Zhu Yu,Bang-Hua Wang,Department of Physiology,School of Basic Medical Sciences,Xianning College,Xianning 437100,Hubei Province,China  
AIM:To investigate the effects of aloe on gastric ulcer in pylorus-ligated rats and to explore potential mechanisms involved.METHODS:Forty-two Wistar rats were randomly divided into three groups:normal control group,ulcer model group and aloe treatment group.Gastric ulcer was induced in rats by ligating the pylorus.The gastric ulcer index (UI),acidity and pepsin activity of gastric juice,and superoxidatase (SOD) activity and malondialdehyde (MDA) level in gastric mucosa were measured in rats of each group.RESULTS:Compared with the normal control group,the UI,acidity and pepsin activity of gastric juice,and MDA level were increased (39.2±2.5 vs 0.0;67.25 mmol/L±7.1 mmol/L vs 41.31 mmol/L±6.3 mmol/L,t=7.2256;171.25 U/mL±29.25 U/mL vs 98.34 U/mL±21.13 U/mL,t=5.3453;0.57 NU/mg pro±0.12 NU/mg pro vs 0.31 NU/mg pro±0.11 NU/mg pro,t=4.2207;all P0.01) and SOD activity was decreased (t=8.2339,P0.01) in the ulcer model group.Compared with the ulcer model group,the UI,acidity and pepsin activity of gastric juice,MDA level were decreased (t=11.7584,6.4310,3.0276 and 5.1428,respectively;all P0.01) and SOD activity was increased (t=5.3003,P0.01) in the aloe treatment group.CONCLUSION:Aloe improves gastric ulcer in pylorus-ligated rats possibly by inhibiting lipid peroxidation,gastric acid secretion and pepsin activity.
【CateGory Index】: R285.5
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