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《World Chinese Journal of Digestology》 2010-34
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Expression of PCNA and C-fos proteins in the human fetal esophagus

Xue-Hong Liu,Yong Zhang,School of Medicine,Shaox-ing University,Shaoxing 312000,Zhejiang Province,China  
AIM:To investigate the expression pattern of proliferating cell nuclear antigen(PCNA)and c-Fos proteins in the human fetal esophagus.METHODS:The expression of PCNA and c-Fos in the esophagus tissue samples taken from hu-man fetus at 2,3 or 4 months was detected by immunohistochemistry.The integral absorbance(IA)values of PCNA and C-fos staining were calculated using the Nikon imaging system(NIS-DR).One-way ANOVA was applied to compare these IA values.RESULTS:Positive PCNA protein expression was detected in all the layers of the esophagus of human fetus at 2,3 or 4 months.The IA value of PCNA-positive cells in the esophagus of human fetus at 2 months was significantly lower than those at 3 and 4 months(50.6540±5.92400 vs 57.8465±9.99749 and 69.3626±16.28008,both P 0.01).With the increase in fetal age,the IA val-ues of PCNA-positive cells showed an upward trend.Positive expression of C-fos protein was also detected in all the layers of the esophagus of human fetus at 2,3 or 4 months.The IA value of C-fos-positive cells in the esophagus of hu-man fetus at 3 months was significantly higher than those at 2 and 4 months(83.2524±8.63989 vs 77.7867±12.22991,66.5414±9.06673,both P 0.01).With the increase in fetal age,the IA value of C-fos-positive cells rose initially and then dropped.CONCLUSION:PCNA and C-fos proteins play an important role in regulating the growth and development of the human fetal esophagus.
【Fund】: 浙江省教育厅科研计划基金资助项目 No.Y200805569;; 绍兴文理学院重点基金资助项目 No.08LG1018~~
【CateGory Index】: R321
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