Role of focal adhesion kinase in the pathogenesis of colorectal carcinoma
Dan-Hua Zhang, Jian-Ping Zhou, Department of General Surgery, the First Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Focal adhesion kinase (FAK) was initially identif ied as a nonreceptor protein tyrosine kinase localized to the focal contact protein clusters. This enzyme has been shown to facilitate generation of integrin-stimulated signals to downstream targets. It has been reported that activation of FAK leads to a number of processes, including cell attachment, migration, proliferation, and survival. The expression of FAK in colon carcinoma is significantly higher than that in matched cancer-adjacent normal tissue, suggesting that FAK may be an important target for the therapy of colon carcinoma. The inhibition of FAK activation can interrupt many signal pathways involved in colon carcinogenesis and may represent a new therapy strategy for colon carcinoma.