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《World Chinese Journal of Digestology》 2011-21
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Rosiglitazone inhibits cell invasion and metastasis in human gastric cancer cell lines SGC7901 and SGC7901/VCR

Hong-Hui Chen, Li Zhang, Can Liu, Zhen-Zhen Ou Department of Gastroenterology, the Second Affiliated Hospital of Nanhua University, Hengyang 421001, Hunan Province, China  
AIM: To investigate the effect of rosiglitazone (ROS) on cell invasion and metastasis in human gastric cancer cell lines SGC7901 and SGC7901/ VCR and to explore possible mechanisms involved. METHODS: Wound healing assay and in vitro invasion assay were used to investigate the antimetastatic activities of ROS in SGC7901 and SGC7901/VCR cells. After treating SGC7901 and SGC7901/VCR cells with ROS (40 μmol/L) for 24 h, the mRNA levels of LIMK1 and cofilin-1 were assessed by reverse transcription-poly-merase chain reaction(RT-PCR), and the protein levels of LIMK1, cofilin-1 and p-cofilin-1 were assessed by Western blot.RESULTS: Treatment with ROS at a concentration of 40 μmol/L for 24 hsignificantly inhibited cellular invasion and metastasis (P 0.05), down-regulated the expression of LIMK1 mRNA and protein and the level of p-cofilin-1 (all P 0.05) but showed no significant impact on cofilin-1-1 mRNA level (P0.05). CONCLUSION: ROS elicited a significant inhibition of in vitro cell migration and invasion in human gastric cancer cell lines SGC7901 and SGC7901/VCR possibly by down-regulating the expression of LIMK1 and inhibiting cofilin-1 activation.
【CateGory Index】: R735.2
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【References】
Chinese Journal Full-text Database 1 Hits
1 LU Hai-bo;DENG Ying-hui;ZHOU Jian-hua;GAO Jing-jing;CHEN Wei;Department of oncology, the Third Affiliated Hospital of Harbin Medical University;;A Study on the Mechanism of Growth Inhibition by Rosiglitazone in the Human Gastric Cancer Cell Line SGC7901[J];现代生物医学进展;2013-30
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Hong-Hui Chen, Li Zhang, Can Liu, Zhen-Zhen Ou Department of Gastroenterology, the Second Affiliated Hospital of Nanhua University, Hengyang 421001, Hunan Province, China;Rosiglitazone inhibits cell invasion and metastasis in human gastric cancer cell lines SGC7901 and SGC7901/VCR[J];世界华人消化杂志;2011-21
2 LI Hui-yan,XIE Xian-he,HOU Mei.Department of Oncology,the People's Hospital of Hainan Province,Haikou 570311,Hainan,CHINA;Clinical significance and expressions of PPARγ in colorectal cance[J];海南医学;2011-12
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