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《World Chinese Journal of Digestology》 2014-11
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Relationship between blood flow assessed by ultrasound, MVD and expression of HIF-1α in hepatocellular carcinoma

Jing-Zhuo Zhang;Ying Liu;Yan-Yan Ma;Department of Ultra-sound,the Second Hospital of Dalian Medical University;Dalian Medical University Postgraduate Department;Medical Center,the Second Hospital of Dalian Medical University;  
AIM: To investigate the ultrasonic signs of hepatocellular carcinoma(HCC), the expression of hypoxia inducible factor-1 alpha(HIF-1α) and microvessel density(MVD), and to analyze their correlations.METHODS: Sixty patients who underwent duplex sonography and color Doppler ultrasonography before surgery and were surgically proved to have HCC were included. Immunohistochemical method was used to detect theexpression of HIF-1α and MVD in HCC. RESULTS: There was a correlation between blood flow grade and MVD. In liver cancer tissues when blood flow classification was grade Ⅲ, the rates of HIF-1α and MVD expression were highest [81.6%(92.61% ± 3.10%), 80.1%(85.16% ± 2.33%)], significantly higher than those in normal liver tissues(12.28% ± 7.21%, 11.33%± 7.21%, P 0.05 for both). The expression of HIF-1α is related closely to hepatocellular carcinoma angiogenesis; higher expression of MVD was associated with higher expression of HIF-1α and more abundant blood flow. CONCLUSION: Combination of color Doppler flow imaging and immunohistochemical parameters is useful for evaluating the angiogensis of HCC.
【CateGory Index】: R735.7;R445.1
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