Clinical study on Smecta in treatment of patients with overful gas in intestinal tract
WANG Jin Hai,LUO Jin Yan,WANG Xue Qin and YU Xiang Yi Department of Gastroenterology, The Second Clinical College, Xian Medical University, Xi'an 710004, Shaanxi Province, China
AIM To evaluate the efficacy and safety of Smecta in treatment of overful gas in intestinal tract of patients with alimentray dyskinesia. METHODS By using a randomized and controlled clinical trial, the changes of symptom score, the amount of expiratory hydrogen H 2 and intestinal gas in 60 patients were observed before and after the treatment. The patients were divided into Smecta group ( n =30) and placebo group ( n =30). RESULTS Compared with placebo, Smecta could significantly decrease the symptom scores, the amount of expiratory hydrogen H 2, and the intestinal gas (0 9±0 2 vs 1 9±0 4,59±21 vs 184±82,16 1±2 4 vs 84 5±8 7, P 0 01). Total efficacy rate of Smecta and placebo were 90 0% and 23 3%, respectively, with a statistically significant difference between the two groups (χ 2=26 936, P 0 01). Side effect of Smecta was mainly constipation (6 7%), but most of the patients could endure. CONCLUSION Smecta can inhibit colonic fermentation of carbohydrates by intestinal bacteria, reduce the amount of intestinal gas and improve the symptoms caused by overful gas in alimentary tract.
【CateGory Index】： R574.4