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《华人消化杂志》 1998-11
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Telomerase activity of exfoliated cancer cells in colonic luminal washings *

JIA Lin and LI Yu Yuan Department of Digestive Diseases, Guangzhou First Municipal Hospital, Guangzhou 510180, Guangdong Province, China  
AIM To detect the value of telomerase activity in exfoliated cancer cells in colonic luminal washings. METHODS Telomerase activity in 16 cases of colorectal tumor, their corresponding normal tissues, exfoliated cancer cells in colonic luminal washings in 16 cases of colorectal tumor and 6 cases of irritable bowel syndrome (IBS) were detected by polymerase chain based telomeric repeat amplification protocol (TRAP) respectively. RESULTS Telomerase activity was strongly positive in 10, weak positive in 3 and negative in 3 cases of tumor tissues, while there was weak positive in 2 and negative in 14 cases in 16 matched normal colonic tissue specimens. The positive rates of telomerase activity in colorectal tumor tissues and normal colonic tissue specimens were 81 3% and 12 5% respectively ( P 0 01). Telomerase activity was detected in washings from 5 (31 3%) of the 16 colon carcinoma cases but not in any cases with IBS. The sensitivity, specificity, positive predictive value and negative predictive value of detection of telomerase activity in luminal exfoliated cancer cells were 31 3%, 100%, 100% and 64 7% respectively. CONCLUSION Telomerase activity in exfoliated cancer cells in colonic luminal washings is a good marker for the detection of colon carcinoma.
【Fund】: 广州市卫生局科研基金
【CateGory Index】: R735.350.4
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