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《China Journal of Bioinformatics》 2007-03
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Analysis of base compositional properties of Arthropod mitochondrial genomes

WU Wei~(1,2) LIU Hong-bin~3 ZHANG Ze~1 LU Cheng~(1*) 1.Key Sericultural Laboratory of Agriculture Ministry,Southwest University,Chongqing 400716,China; 2.College of Computer and Information Science,Southwest University,Chongqing 400716,China; 3.College of Resources and Enviranment,Southwest University,Chongqing 400716,China)  
The unusual characteristics of mitochondrion have prompted us to conduct study of mitochondrial genomes.A comprehensive analysis of base composition properties and the relationship between base composition and amino acid composition in 93 arthropod mitochondrial genomes was carried.Among arthropod mitochondrial genomes,the GC contents of the whole genomes range from 13.28% to 39.64% and are strongly correlated with that of the third codon position (r=0.9432,p0.01).In addition,most major changes in base composition between lineages can be attributed to shifts between the proportions of C and T,A and G.Furthermore,base compositional bias could lead to amino acid bias by compared analysis of NC004529 and NC 003979.The striking variations in base composition exist both within genomes and across species. Thnese results suggest that some genome-wide factors such as GC mutational bias are important for the biased base composition in arthropod mitochondrial genomes.
【Fund】： 教育部博士点学科专项基金(20040625009)
【CateGory Index】： Q953
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