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《Journal of Xinxiang Medical College》 2005-06
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Effects of prolactin on the expression of IL-2R and LFA-1 of T lymphocytes

SHI Ying~(1,2),WANG Hui~1,YIN Xue-nian~2 (1.Faculty of Laboratory Medicine,Xinxiang Medical College,Xinxiang 453003,China;2.Shen zhen Longgang Central Hospital,Shenzhen 518116,China)  
Objective To study effects of PRL(prolactin)on the expression of the IL-2R and LFA-1 of T lymphocytes.Methods The expression of IL-2 receptor alpha chain(IL2Rαchain,CD25αchain) and adhesive molecules LFA-1(CD11) on the surface of T lymphocytes,which was stimulated by prolactin and bromocrytine(BRC),respectively or cosimultaneously,were detected by flow cytometry.Results The expression of IL-2R and LFA-1 of T lymphocytes in PRL-stimulated,BRC-stimulated and PRL-BRC-costimulated groups are significantly higher than those in non-stimulated control groups(P0.05).Conclusion PRL,as an immunoregulator,plays an important regulatory role in functions of T lymphocytes;BRC can't inhibit the PRL-induced activation and proliferation of T lymphocytes in this experiment.
【Fund】: 河南省医学科技创新人才工程重点资助项目(2001013)
【CateGory Index】: R392.1
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