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《Journal of Xinxiang Medical College》 2006-01
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Relationship between expression of iNOS and liver cellular apoptosis following liver ischemia/ reperfusion injury in rats

WANG Hong-mei,ZHANG Jian-long,TENG Qing-lei,et al(Department of Pathophysiology, The College of Pre-clinical Medicine, Xinjiang Medical University, Urmuqi, China,830054.)  
Objective To study the relationship between the expression of inducible nitric oxide synthase (iNOS) and liver cellular apoptosis following liver ischemia/reperfusion(I/R) injury in rats.Methods A model of liver I/R injury was established by imitation.Forty eight male Wistar rats were randomly divided into 6 groups: sham operation,ischemia 30min without reperfusion(group I),reperfusion following ischemia-30min (group I/R).1 hour reperfusion following ischemia 30min(group I/R 1h),2 reperfusion following ischemia 30min (group I/R 2h) and 4 reperfusion following ischemia 30 min (group I/R 4h).The contents of glutamic-pyruvic transaminase (GPT) and alkaline phosphatase (AKP),γ-glutamyl transpeptidase(γ-GT) in the serum were examined,respectively and liver tissue was observed by HE staining.The expression of iNOS in liver tissue were examined by immunohistochemical technique in each group. The changes of hepato- cellular apoptosis were measured by in situ cell apoptosis technique. Results During I/R,the remarkable liver cellular injury can be found,and the liver cellular edema,inflammatory cellular infiltration, even cellular necrosis and matched enzyme in serum increased. The contents of iNOS rose in I group (P0.01)and reached to the peak in I/R4h group.Apoptosis exponent in group I/R was significantly higher than that in group of sham operation(P0.01),and the exponent was increasing endlessly following the process of reperfusion injury .And there was a positive corelation between the expression of iNOS and apoptosis exponent (P0.01,r=0.952).Conclusion Liver I/R injury leads to liver tissues injury as well as liver cellular apoptosis.The development of liver cellular apoptosis is related to the expression of iNOS.
【CateGory Index】: R575
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