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Relationship between pregnancy-associated Plasma Protein A,C-reactive Protein and metabolic syndrome

KE Hai-xia,JIA Yin-ming,HAN Qin-fu,et al(Department of Cardiovasculary,Anyang People′s Hospital,455000)  
Objective To investigate the relationship between pregnancy-associated plasma protein-A(PAPP-A),C-reactiveprotein(CRP) and metabolic syndrome(MS).Methods The level of serum PAPP-A in fifty patients with MS and 30 healthy subjects were detected by Enzyme-linked immunosorbent assay(ELISA).Serum CRP,fasting plasma glucose(FPG),blood pressure(BP),waist circumference(WC),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C) were detected routinely.Correlation analysis between PAPP-A,CRP and MS was studied.Results The serum levels of PAPP-A and CRP were significantly higher in observation group than these in control group(P0.01).Highly positive correlation between the serum concentration of PAPP-A and CRP,WC,BP,TC,TG were observed(r=0.422,0.396,0.296,0.564,0.289,P0.05),and significant negative correlation between serum level of PAPP-A and LDL-C,ApoA-I/ApoB were found(r=-0.450,r=-0.355,P0.05).Conclusion PAPP-A and CRP play an important role in the pathogenesis of MS,and both PAPP-A and CRP are predict risk factors of cardiovascular disease.
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