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《Journal of Xinxiang Medical College》 2008-03
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Influence of puerarin preconditioning on calcium content in brain tissues of rats with cerebral ischemical reperfusion injury

PAN Deng1,TAN Jun2,SUN Zhao-yin3(1.Veteran Cadre Department,the First People′s Hospital of Xinxiang City,Xinxiang 453000,China;2.Department of Neurology,the Third Affiliated Hospital of Xinxiang Medical College,Xinxiang 453003,China;3.Department of Postgraduate,Xinxiang Medical College,Xinxiang 453003,China)  
Objective To observe the influence of puerarin preconditioning on calcium content in brain tissues of rats with cerebral ischemical reperfusion injury,to probe its potential genetic mechanism,and to provide evidences for puerarin clinical application.Methods Ischemic middle cerebral artery occlusion(MCAO) was taken 2 h before the rat models were treated with reperfusion injury.Seventy-two Spranue-Dawley(SD) rats were randomly divided into sham operation group(SO group),ischemia reperfusion group(IR group) and puerarin preconditioning group.Each group was divided into three subgroups according to the time of killing the rats,8 rats in each subgroup.Calcium content was determined by automatic biochemistry analyzer.Results Twenty four hours,72 h,and 120 h after the surgery,Calcium contents of the IR group were higher than those of the SO group,respectively(P0.05);and also higher than those of the puerarin preconditioning group(P0.05).Conclusion Puerarin preconditioning can significantly reduce calcium content in murine brain with focal cerebral ischemia and can protect brain tissues.
【Fund】: 河南省高等院校中青年骨干教师资助项目(编号:2005061)
【CateGory Index】: R285
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