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《Journal of Xinxiang Medical College》 2008-06
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Inhibitory Effects of enmein、serrin B、nodosin and lasiodonin on growth of HL60 cells and LOVO cells in vitro

HAI Guang-fan,YAN Yan,LIU Ju-yuan,et al(Department of Pharmacology,Pharmacy College of XinXiang Medical College,Xinxiang 453003,China)  
Objective To study the inhibitory effects of enmein,serrin B,nodosin and lasiodonin on growth of HL60 cells and LOVO cells in vitro.Methods The cytotoxicity of enmein,serrin B,nodosin and lasiodonin on HL60 cells and LOVO cells were determined with MTT colorimetric assay.Results Enmein,serrin B,nodosin and lasiodonin could all to some extent inhibit the growth of HL60 cells and LOVO cells in vitro.Their inhibitory effects were more obvious with dose rising,which took on dose-effect relationship.Conclusion Enmein,serrin B,nodosin and lasiodonin are the active components of Rabdosia serra(Maxim) Hara,which can offer more choice for the treatment of leukemia and colon carcinoma.
【Fund】: 新乡医学院高学历人才资助项目(2007)
【CateGory Index】: R285
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