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《Chinese Journal of Information on TCM》 2004-08
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Determination of Chlorogenic Acid in Yinhuang Preparation by HPLC

GAO Yong-li (Shenzhen City Institute for Drug Control, Shenzhen 518029, China)  
Objective To establish a HPLC method for the determination of Chlorogenic Acid in Yinhuang preparation-Yinhuang tablet. During the determination of Chlorogenic Acid in Yinhuang oral liquid, the method is been compared with the UV method, offer gist for a more exactitude standard to control its quality. Methods A Hypersil ODS C18 column (5 μm, 150 mm×4.6 mm) is used with a mobile phase of methanol-water-acetic acid glacial-triethylamine (15∶85∶1.5∶0.3), the velocity of flow is 1.0 mL/min, the detect wavelength is 327 nm. Results The average recovery of Chlorogenic Acid is 98.92%, RSD=1.45%. Conclusion The method was simple, sensitivity and stable, and can be used as the method of quality control for Yinhuang tablet. The result that detected by UV method is not the actually concentration of Chlorogenic Acid. HPLC can detect it exactly, and is easier, more rapidly, fit for the quality control of Yinhuang preparation.
【CateGory Index】: R286
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【References】
Chinese Journal Full-text Database 1 Hits
1 Li Junqing,Li Zhanfang,Song Jianjian and Quan Qinbo(Dongying Institute for Drug Control,Dongying 257091);Determination of Chlorogenic Acid in Lianhua Qingwen Capsules by HPLC[J];Chinese Pharmaceutical Affairs;2011-02
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1 Chen Guoqiang Yang Hongqing Wujun Feng Qunying(Yiwu 322000 Yiwu Institute for Drug Control) Wu Shaoming(Jinhua 321000 Jinhua Institute for Drug Control);Determination of Chlorogenic Acid and Baicalin in Yinhuang Oral Solution by HPLC[J];Chinese Journal of Modern Applied Pharmacy;2001-04
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 Zheng Chunying , Xiao Hongbin (Heilongjiang University, Harbin 150080);Pharmacokinetic study of chlorogenic acid in the TCM preparation Miyankang[J];Journal of Beijing University of Traditional Chinese Medicine;2005-01
2 GE Yu-song1, YANG Jin-jing2, ZHOU Hui-qin1 (1.Jiangsu Province Yancheng Institute for Drug Control,Yancheng 224002,China;2.College of Pharmacy,Nanjing University of Chinese Traditional Medicine Institute,Nanjing 210046,China);Improvement on quality standard for Yinhuang Injection[J];China Medical Herald;2009-05
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1 Wang Zhaohui Li Luming Sun Jianmin Zhang Deqiang Sun Hanwen (Department of Chemistry,Hebei University, Baoding 071002);Determination of Iron and Zinc in Milk Powder by Closed Vessel Micro wave Digestion and Derivative Flame Atomic Absorption Spectrometry[J];JOURNAL OF HEBEI UNIVERSITY(NATURAL SCIENCE EDITION);1998-03
2 DU Hong xia 1,SUN Feng xia 1,ZHAO Wen xia 2,GE Yan rui 1,RONG Jie 1 (1.College of Chemical and Pharmacy Engineering,Hebei University of Science & Technology Shijiazhuang Hebei 050018,China;2.College of Environmental Science and Engineering,Hebei;The New Advances in Flame Atomic Absorption Spectrometer[J];Journal of Hebei University of Science and Technology;2002-02
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1 WANG Ke1a,WANG Yan-yan1a,ZHAO Dong-bao1a,2,LIU Xiu-hua1a,1b,LI Ming-jing1a,XU Ping-hui3(1.Henan University a.Environmental and Analytical Science Institute of College of Chemistry and Chemical Engineering b.Key Lab of Natural Drug and Immune Engineering,Henan Kaifeng 475004,China;2.Jiyuan Vocational and Technical College,Henan Jiyuan 454650,China;3.Xinxiang Biocaro Biotech Co.LTD,Henan Xinxiang 453000,China);Determination of the Contents of Luteolin and Luteoloside in Different Parts of Lonicera japonica by HPLC[J];Journal of Henan University(Natural Science);2011-01
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1 Zhang Zhongyi,Tan Xuanzhong Nanjing Muncipal Hospital of Traditional Chinese Medicine,Nanjing,210001;Investigation on Relationship between Fry-time of Radix Scuteliariae with Wine and Its Components[J];Chinese Traditional Patent Medicine;1993-10
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