A Study in Effect of Artemisinin and its Derivatives on Reversion of Multi-drug Resistance of Tumors
LU Cui-yan1, CHEN Xin-Yi1, TANG Bing-hua2 (1.Dongzhimen Hospital of Beijing University of TCM, Beijing 100700, China;2.Basic Medicine School, Beijing University of TCM, Beijing 100029, China)
Objective Effect of artemisinin and its derivatives on multi-drug resistance of tumor cells. Method The inhibition of cell proliferation and RI (reversal index) were determined by MTT method. Results The inhibitory effect of dihydroartemisinin and artemisunate on the proliferation of tumor cell is stronger than that of artemisinin. Artemisinin could partly improve KBv200 cell sensitivity to VCR in different concentrations. Conclusion Artemisunate and dihydroartemisinin effectively inhibited the proliferation of KBv200. Artemisinin could partly improve KBv200 cells sensitivity to chemotherapy medicine.