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《Chinese Journal of Information on Traditional Chinese Medicine》 2011-01
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Effect of Shenlongjiannao Capsule on Oxidation Damage and Acetylcholine Neurotransmitter in Cortex of Chronic Cerebral Ischemia Rats

ZHANG Gang,XU Cheng-yong,GENG Miao,CHEN Li-ping,WANG Fa-wei(General Hospital of PLA,Beijing 100853,China)  
Objective To explore the protective effects of Shenlongjiannao capsule on rats with cerebral ischemia.Methods The cerebral ischemia animal model was established by two-vessel occlusion.Fifty rats were randomly divided into 5 groups:control group with sham operation,model group,positive control group of pisacetam,Shenlongjiannao capsule groups(low and high dosage).Four weeks later,SOD,oOH,MDA and AchE in cortex was measured.Result Shenglongjiannao capsule decreased the contents of MDA and·OH in cortex of cerebral ischemia rats,and improved activities of SOD and AchE.Conclusion Shenlongjiannao capsule may play protective role on rats with chronic cerebral ischemia.
【Key Words】: Shenlongjiannao capsule cerebral ischemia hydroxyl free radical superoxide dismutase malondialdehyde acetylcholinesterase rats
【Fund】: 北京市科委科技计划研发攻关基金(Z07050700690709)
【CateGory Index】: R285.5
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