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《Chinese Journal of Information on Traditional Chinese Medicine》 2011-06
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Safety Study on Zhuhong Ointment of Promoting Dermal Ulcer Healing

DONG Jian-xun1,LUO Ling2,LI Jian-rong 3,WANG Le-ping 2,HE Rong 3,PENG Bo 3,XU Qi-hua 3(1.Beijing Hospital of Chinese Medicine, Capital Medical University,Beijing 100010,China;2.Beijing University of Chinese Medicine,Beijing 100029,China; 3.Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China)  
Objective To study the safety of Zhuhong Ointment in promoting dermal ulcer healing and to provide the basis for clinical administration.Method Sixty-six male SD rats were randomly divided into the damaged skin group,ulcer model group,vaseline control group,and high-,middle-,low-dose Zhuhong ointment groups.Each group was treated by corresponding methods for 14 d.NAG and RBP contents in urine were taken as monitoring indexes,and the pathological morphology changes of kidney were observed. Results There was no significant difference in NAG content between Zhuhong Ointment groups and ulcer model group(P0.05).The RBP content in ulcer model group was remarkably lower than other groups(P 0.05,P0.01).Kidney pathological changes of high-dose Zhuhong ointment group were significantly increased than that of damaged skin group(P0.05).Conclusion Middle dose of Zhuhong Ointment used for 2 weeks can be regarded as safe.High dose of Zhuhong Ointment used for 2 weeks may cause renal injury.
【Fund】: 国家科技支撑计划(2008BAI53B085)
【CateGory Index】: R285
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