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《Chinese Journal of Information on Traditional Chinese Medicine》 2012-02
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Effects of Traditional Chinese Complex Prescription Containing Iodine on Serum Antithyroid Antibodies of Experimental Autoimmune Thyroiditis Rats

DENG Cui,ZHANG Lan,JIANG Wei-na,ZHU Xiao-dan,FANG Zhen-wei(Liaoning University of TCM,Shenyang 100847,China)  
Objective To investigate the effects of the traditional Chinese complex prescription containing various doses of iodine in treating experimental autoimmune thyroiditis(EAT) rats by observing serum anti-thyroid antibodies and the weight of thyroid.Methods An animal model of EAT rats was developed by injecting thyroglobulin mixed with complete Freund's adjuvant immunization and incomplete Freund's adjuvant immunization,and feeding with high iodine water.All the rats were divided into four groups randomly:EAT group,the low-dosage,medium-dosage,and high-dosage of Chinese prescription group.After six weeks' treatment,all rats were dissected,blood were collected,the levels of TgAb,TPOAb and the weight of thyroid(thyroid/body) were detected.The results were compared with normal group.Results The levels of serum anti-thyroid antibodies of all groups were significantly lower than that of EAT group.The thyroid weight index of EAT group was higher than that of normal group.The thyroid weight index of all treatment groups were lower than that of EAT group.The thyroid weight index of the high-dosage treatment group was lower than that of the low-dosage treatment group(P0.05).The difference between the medium-dosage treatment group and the high-dosage treatment group was not obvious(P0.05).Conclusion The mechanism of traditional Chinese complex prescription in treating antoimmune thyroiditis may be related with decreasing the levels of TgAb and TPOAb,and the effect depends on the dosage of iodine.
【Fund】: 辽宁省科学技术基金(20092038)
【CateGory Index】: R285.5
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【References】
Chinese Journal Full-text Database 1 Hits
1 ZHOU Lijing;HAN Jing;The Graduate School of Heilongjiang University of Traditional Chinese Medicine;The Internal Medicine of Outpatient Service in Second Hospital Affiliated to Heilongjiang University of Traditional Chinese Medicine;;Discussion on Chinese herbal with iodine and its compound prescription in treating thyroid diseases[J];中国医药科学;2014-01
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Zhong Liu-pei Zhong Jing(Community health service center of Shilong town,Dongguan 523320,China Donghua Hospital,Dongguan 523001,China);The clinical analysis of mastoplasia treated with Haizao Yuhu decoction[J];内蒙古中医药;2013-21
2 ZHANG Ying,Advisor :ZHANG Lan(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China);Discussion on Application of Chinese Medicine with Iodine in Treatment of Chronic Lymphocytic Thyroiditis[J];辽宁中医药大学学报;2013-07
3 ZHANG Lan1,ZOU Xiaoning2,JIANG Weina1,YANG Binjie2,FAN Chengcheng2(Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032 Liaoning,China);Effect of Iodine-Containing Chinese Herbal Recipe on Apoptosis-regulation Protein Fas/FasL and Bcl-2/Bax in Thyroid Tissue of Autoimmune Thyroiditis Rats[J];中药新药与临床药理;2013-02
4 BI Xiao-juan TANG Hong Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine;Progress on Treatment of Hyperthyroidism with Herbal Medicines Containing Iodine[J];上海中医药大学学报;2012-05
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6 DENG Cui,ZHANG Lan,JIANG Wei-na,ZHU Xiao-dan,FANG Zhen-wei(Liaoning University of TCM,Shenyang 100847,China);Effects of Traditional Chinese Complex Prescription Containing Iodine on Serum Antithyroid Antibodies of Experimental Autoimmune Thyroiditis Rats[J];中国中医药信息杂志;2012-02
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