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《Journal of Experimental Hematology》 1993-01
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EFFECT OF ANGELICA POLYSACCHARIDE ON GRANULOPOIESIS AND MONOCYTOPOIESIS IN MICE

Ya-ping Wang Bi-De Zhu (Chongqing University of Medical Sciences Chongqing 630046)  
Angelica Sinensis (Oliv) Diels is a well-known important drug in hematonic and invigorating the circulation of blood. Angelica Polysaccharide(AP)is known as one of the main effective fractions in Angelica Sinensis. By using the techniques of culture of hemopoietic progenitor cell in vitro, we studied the effect of AP on granulopoiesis and monocytopoiesis in mice. The results indicated that AP can augment powerfully the proliferation of CPU -GM by the injection of AP in vivo; There is almost no effect on proliferation of CFU-GM by alterations in the concentration of AP in culture media in vitro; The growth of CFU-GM is enhanced significantly in the presence of additional spleen cell conditioned media or supernates of cultured peritoneal macrophage prepared by adding AP into culture media in vitro or by the injection AP in vivo; The skeletal muscle conditioned medium, which is prepared by the injection of AP in vivo, has much stronger stimulating activity on proliferation of CFU-GM; Granulopoiesis and monocytopoiesis in bone marrow are promoted by the injection of AP in vivo; AP can increase the number of peripheral leukocytes in anemic mice. Our research suggests that AP may enhance strongly the proliferation of CFU-GM; intensify the granuolopoiesis and monocytopoiesis in bone marrow and increase the number of peripheral leukocyte by stimulating, directly and / or indirectly, macrophage, lymphocyte in hemopoietic inductive microenvironment, also by promoting the secretion of CSF-Like factors from muscle cells indirectly.
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