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《Journal of Experimental Hematology》 2008-04
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Measurement of Serum Free Light Chains and Its Clinical Significance in 20 Newly Diagnosed Patients of Multiple Myeloma

MAO Xiao-Bei1,2,CHEN Xie-Qun1,ZHAI Yong-Ping2,LIANG Rong1,GAO Guang-Xun1,MA Guo-Guang2,YU Ya-Ping2,LI Feng21Department of Hematology,Xijing Hospital,The Fourth Military Medical University,Xi′an 710032,Shaanxi Province,China;2Department of Hematology,Nanjing General Hospital of Nanjing Military Area,Nanjing 210002,Jiangsu Province,China  
The objective of this study was to explore the clinical significance of measuring serum free light chains(sFLC) and to compare with serum total light chains(free and binded) in multiple myeloma(MM).sFLC in 20 newly diagnosed MM patients and 20 cases of healthy people as control were measured by immuno-nephelometric assays;the serum light chains and κ/λ ratio were measured in all patients,while immunofixation electrophoresis(IFE) tests were carried out at the same time in 18 out of 20 patients.The results showed that the abnormality of serum free light chains and κ/λ ratio were found in all of the 20 newly diagnosed MM patients(p0.01).The measurement of sFLC showed higher sensitivity than the total serum chains(p0.01).It is concluded that the method testing sFLC by immuno-nephelometric assay combined with κ/λ ratio is valuable for MM diagnosis,and the measurement of sFLC can be used as one of indicators for MM diagnosis.
【Fund】: 南京军区总医院面上课题资助 编号200614
【CateGory Index】: R733.3
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【References】
Chinese Journal Full-text Database 1 Hits
1 LIN Xiao-yan,et al.(Xiamen Center of Clinical Laboratory,Zhongshan Hospital,Xiamen,Fujian 361004 China);The clinical significance of Hb n Serum A/G,Hs GRP in multiple myeloma[J];Journal of Qiqihar Medical College;2009-15
【Citations】
Chinese Journal Full-text Database 1 Hits
1 LI Hua,ZHAI Tan.Department of Clinical Laboratory,Donghua Hospital of Zhongshan Medical University,Dongguan,Guangdong 523100,China;Role of serum κ/λ ratio detection in multiple myeloma diagnosis[J];International Journal of Laboratory Medicine;2006-02
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 SHI JING,CUI ZHONG-GUANG,WANG HONG-YI(Qingdao University Medical College,Qindao 266021,China);DETECTION OF SERUM FREE LIGHT CHAIN AND ITS CLINICAL SIGNIFICANCE IN PATIENTS WITH MULTIPLE MYELOMA[J];Medical Journal of Qilu;2011-03
2 Wan Tang,Zhang Min,Gong Jing-lian,Wang Xiao-gang,Huang Guang-ping(The First Hospital of Nanchang City,Nanchang 330008,China);Clinical value of serum albumin electrophorsis for multiple myeloma[J];Chinese Journal of Health Laboratory Technology;2007-10
【Co-references】
Chinese Journal Full-text Database 1 Hits
1 ZHOU Sheng-yu, CAI Xiao-yan. Department of Hematology, Anhui Provincial Hospital, The Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei Anhui 230001, China.;Prognostic significance of hemoglobin level in multiple myeloma[J];Journal of Clinical and Experimental Medicine;2008-04
【Secondary Citations】
Chinese Journal Full-text Database 3 Hits
1 QI Wei-Min;GUO Li(Department of Clinical Laboratories, Tangdu Hospital, Fourth Military Medical University, Xi'an710038);Diagnostic application of quantitation of kappa,lambda light chains and its ratio in patients with multiple myeloma[J];JOURNAL OF THE FOURTH MILITARY MEDICAL UNIVERSITY;1998-04
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3 Xu Jiangxia,Liu Ming, Wan Jianxin,Yu Chunshan.Department of Laboratory,Fourth Affiliated Hespital,Jiangxi Medical college,Nanchang 330003;Determination of the immunoglobulin and light chains and its clinical significance in patients with Multiple Myeloma[J];JIANGXI JOURNAL OF MEDICAL LABORATORY SCIENCES;2000-01
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