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《Journal of Jiangxi University of Traditional Chinese Medicine》 2007-03
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Effect of Shengjiang Powder on Expression of ICAM-1 of Lung Bronchiolar Epithelium Mucosae in Acute Lung Injury Rats

WEI Kai-feng,CHANG Jia-song,ZHANG Mei-yong,ZHANG Qing-hong,PAN Yun Nanjing University of Traditional Chinese Medicine,Nanjing210029  
Objective:To investigate the effect of Shengjiang Powder on expression of ICAM-1 of lung bronchiolar epithelium mucosae in acute lung injury rats.Methods:Totally 40 healthy SD male rats of which were divided into 5 groups by random:control group,model group,Shengjiang powder high-,low-and middle-dose groups.At the 6th day after administration,reproduce acute lung injury rat models by injecting LPS into sublingual vein.Detected the expression of ICAM-1 by assessing lung histological sections by immmunohistochemistry.Capture the images and measured the average gray values of cytoplasm of lung bronchiolar epithelium mucosae.Results:Compared with model group,Shengjiang Powder could depress the expression of ICAM-1 in the cytoplasm of lung bronchiolar epithelium mucosae,statistical difference existed between treating groups and model group.Conclusion:Shengjiang Powder can preventing and treating acute lung injury by inhibiting inflammatory damage on lung tissues through depressing the expression of ICAM-1 in the cytoplasm of lung bronchiolar epithelium mucosae.
【Fund】: 南京中医药大学校自然科学基金(No.05XZK01)
【CateGory Index】: R285.5
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