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《新药与临床》 1988-05
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l-Stepholidine for oral treatment of hypertension

CHENG Quan-Ru, LIAO Gang Wept of Medicine, First Hospital of Nanchang, Nanchang 330012) SUN Zhou (Deft of Pharmacology, Jiangxi Medical College, Nanchang 330006) JIN Guo-Zhang (Shanghai Inst Materia Medica, Chinese Academy of Science, Shanghai 200031)  
l-Stepholidine(SPD) was used to treat 35 patients with essential hypertension at the dosage of 50 mg tid for a single course of 30 days, The lowering of blood pressure attained 3.4+2.5/1.8+1.3kPa(25+18/14 + 9 mm Hg). The effective rate was 83%.The antthypertensive effect had a 7 d latency of onset and maintaind a 10-30 d duraion after withdrawal. Synergism was observed when SPD 25 mg tid was used in combination with 1 tablet tid of the composite antihypertensive drug "Fu-Fang-Jiang-Ya-Pian" The abnormal effect of raising blood pressure was observed in 1 patient when SPD po 50 mg tid was adminstered together with an injecteon of 1 mg reserpine.No obvious toxic effects on heart, liver and kidney were found.
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