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Identification and clinical study of placental immunoregulating polypeptides

PENG Li-Yi, YANGDao-Li, QI Fa-Lian, KE Bing-Shen, JIA Bo-Sen, ZHQNG Ren-Qian (Department of Immunology, General Hospital of Ji-nan Military Region, Ji-nan 250031)  
Accroding to the Lawrence's method, a kind of dialyzable, ultrafil-terable and heat labile polypeptides co-ntaining 16 amino acids were prepared from human placental tissue.Comparative studies revealed that it was not substantially the same as transfer factor(TF), it was considered as a new immune regulator, namely, the placental immunoregulating polypeptides(PIRP). It was safe, had no adverse effects to human body, promoted the growth of BALB/c mice, transformed PHA skin test from negative to positive ia 95.2%cases and recovered the active rosette formation reduced by culture at 37C The improveme-nt of cell-mediated immunological function with PIRP in 164 clinical cases suggested that PIRP is a reasonable immunoregulator.
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