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《Chinese Journal of New Drugs and Clinical Remedies》 2000-02
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Methylcobalamin in treatment of lower lumbar vertebral diseases: Phase Ⅲ clinical trials

GONG Yao-Cheng, LIAN Yu (Ruijin Hospital, Shanghai Second Medical University, SHANGHAI 200025, China )  
AIM: To evaluate the efficacy and safety of methylcobalamin in treating lower lumber vertebral diseases. METHODS: Ninety patients (M 56, F 34, age 48 a+- s 45 a and 53 a+- 32 a) of lower lumbal vertebral diseases were consisted of 72 Patients of lumbar intervertebral disk herniation and 18 of lumbar intervertebral Canal stenosis. all patients received methylcobalamin 500 ug, im, qod in the first 2 wk and then methylcobalamin 500 ug, po, tid in the following 2 wk. RESULTS: The clinical symptoms and signs in most patients were obviously improved, especially the subjectve symptoms. An improvement ratio of total was 45% above the effective level and 84% above the improved level. No differences of improvement ratio were found in statistics among the two diseases, different affected durations, the presence and absence of analgesic. CONCLUSION: Methylcobalamin is considered to be useful and safe to the improvement of pain, numbness, and other nerve disturbance symptorns associated with lumbar vertebral diseases. Methylcobalamin clinical trial cooprative group: GONG Yao-Chen, Lian Yu (Ruijin Hospital, Shanghai Second Medical university, SHANGHAI 200025, China ); ZHANG Guang-Jian (Zhongshan Hospital, Shanghai Medical University, SHANGHAI 200032, China ); HE He-Gao (Shanghai 6th People's Hospital, SHANGHAI 200233, China); JIA Lian-Shun, YUAN Wen (Shanghai Changzheng Hospital, SHANGHAI 200003, China ); ZHANG Chun-Cai (Shanghai Changhai Hospital, SHANGHAI 200433, China ); CHENG Yong-Qiang (Shanghai 9th people's hospital, SHANGHAI 200011, China )
【Key Words】: methylcobalamin spinal stenosis intervertebral disk displacement lumbar vertebrae
【CateGory Index】: R681.5
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