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《Chinese Journal of New Drugs and Clinical Remedies》 2002-04
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Clinical effect of Lactobacillus acidophilus for Helicobacter pylori

WANG Xue ming 1, LI Nan 2, ZHOU Jian fei 2, ZHU Chao hui 2 (1.Department of Pharmacoly, The 309th hospital of PLA, BEIJING 100091,China; 2.Department of Gastroenterology, The 309th Hospital of PLA, BEIJING 100091, China)  
AIM: To observe the therapeutical effect of Lactobacillus acidophilus for human stromach Helicobacter pylori. METHODS: The gastric ulcer and duodenal ulcer patients of Hp positive sixty eight patients were divided into two groups, Lactobacillus acidophilus treatment group (twenty four patients, Lactobacillus acidophilus one packet, po, bid, ulcermin sheet 1.0 g, po , tid) and control group (forty four patients, and ranitidine 0.15 g, po, bid, metronidazole 0.4 g, amoxicillin 0.5 g, ulcermin sheet 1.0 g, po, tid) administrated for 4 wk. Then the clinical symptom recovery, gastric mucosa Hp infection condition and Cag Hp IgG changes were observed. RESULTS: Symptom remission rate: the treatment group was 100%(12/12) and the control group was 95%(18/19). Ulcer healing rate of two groups were 100%(15/15) and 97%(40/41) in difference; there was not significantly different in the two groups ( P 0.05); (3) Hp infection rate: two groups were 67%(16/24) and 75%(33/44) in difference; Enzyme linked immunodson dent assay (ELISA) detect of serolog CagA +IgG Gene expression: Anti exprossion positive of two groups in pre treatment were 62% and post treatment positive findings 30%, there was not significantly different in two groups ( P 0.05). CONCLUSION: The study suggest Lactobacillus acidophilus has significant effect on anti Hp infection and mediate body immunity.
【CateGory Index】: R573
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