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《Chinese Journal of New Drugs and Clinical Remedies》 2003-11
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Randomized double-blind controlled study of oxiracetam vs piracetam in treatment of vascular dementia

Hai li bi nu er, WANG Yin hua, ZHAO Fa guo (Department of Neurology, The First Hospital of Peking University, BEIJING 100034, China)  
AIM:To compare the therapeutic effect and safety of oxiracetam and piracetam in the treatment of mild or moderate vascular dementia (VD). METHODS: The multicenter, randomized, double blind, positive controlled clinical trial was applied. Sixty patients with mild or moderate vascular dementia (MMSE score:10 21) were divided into oxiracetam group ( n=30 ) and piracetam group ( n=30 ) randomly. The MMSE scale and Blessed Roth scale were applied in evaluating the therapeutic effect before and after treatment of oxiracetam or pricacetam 800 mg, po , tid, for 60 d. RESULTS: All the indexes, except that of daily life abitity improved after tretemnt in two groups compared with that of pre treatment, there were very significant or significomt differences ( P 0.01 or P 0.05). The amelioration of soial activity (difference value was 0.7± s 1.1 between pre and post therapy) had very significant difference ( P0.01 ) in oxiracetam group, however, that in priacetam group (difference value was 0.5±1.1 between pre and post therapy) had only significant difference ( P 0.05). But the extent of amelioration of these indexes had no significant difference ( P 0.05) in two groups. CONCLUSION: Oxiracetam and piracetam had similar therapeutic effect and safety on VD.
【CateGory Index】: R749.13
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