Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of New Drugs and Clinical Remedies》 2007-02
Add to Favorite Get Latest Update

Efficacy and safety evaluation of edaravone injection in treatment of acute cerebral infarction:a multicenter,double-blind,and randomized controlled clinical trial

ZHANG Ming,XU Li-jun,DENG Li-ying,LU Jie,REN Hui,YANG Qi-dong,HU Zhi-ping,GUO Chong-lun,MO Jia-peng (Department of Neurology,the Second Affiliated Hospital of Nanchang University,Nanchang JIANGXI 330006,China;Department of Neurology,the Frist Affiliated Hospital of Kunming Medical College,Kunming YUNNAN 650032,China;Department of Neurology,Xiangya Hospital of Central South University,Changsha HU-NAN 410008,China;Department of Neurology,Xiangya Second Hospital of Central South University,Changsha HU-NAN 410008,China)  
AIM:To evaluate the clinical effects and safety of edaravone injection on acute cerebral in- farction (ACI). METHODS:A multicenter, randomized, placebo-controlled, parallel, double-blind trial was carried out on patients with ACI. Two hundred and two patients were randomly allocated to treatment group (n = 100) and control group (n = 102). Besides the basic treatment, the individual in treatment group received edaravone 30 mg dissolved in sodium chloride injection 100 mL, twice a day, for 14 d, while that of the control group received similar quantity of sodium chloride injection to those of edaravone group but without edaravone. Before treatment and at 7 th, 14 th and 28 th day after treatment, the neurological deficits and activities of daily living (ADL) were evaluated using European Stroke Scale (ESS) and Bathel index respectively. RESULTS: After 28 d of treatment, the effective rates of ADL in treatment group and control group were 77.0 % and 27.4 % respectively (P 0.000 1), while those of the neurological deficits (ESS) were 78.0 % and 26.5 % respectively (P 0.000 1). The adverse reactions occurred as 4.0 % and 6.9 % (P 0.05) in the former and later group, showing no significant difference. CONCLUSION: Edaravone injection provides effective improvements for both neurological deficits and ADL in ACI without conspicuous adverse reactions.
【Key Words】: edaravone free radical scavengers cerebral infarction drug evaluation double-blind method randomized controlled trials
【CateGory Index】: R743.3
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 10 Hits
1 Jiang Meifang,et al Shenzhen Baoan District People's Hospital(518101);Research Progress of Edaravone Clinical Application for Different Diseases[J];Heilongjiang Medicine Journal;2009-04
2 Liu Liyan,Ji Xiaoyu.East Hospital,the First People's Hospital of Lianyungang City,Lianyungang 222042,China;Clinical observation of edaravone and ozagrel in the treatment of progressive cerebral infarction[J];Chinese Journal of Practical Nervous Diseases;2011-19
3 Wang Yuyong.Shangqiu Central Hospital,Shangqiu,Henan 476000,China;Clinical efficacy of in Edaravone in treatment of acute cerebral infarction on neurological impairment and activities of daily living[J];Chinese Journal of Practical Nervous Diseases;2012-17
4 LEI Ling-yan1,SUN Lei-lei,XIE Lu,HUANG Qiao-juan,CHEN Xiao-yang, ZHUO Xiao-jun,CHEN Meng-hua(1 The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,P.R.China.);Effect of edaravone on prolonged survival and neurological function in a rat model of cardiopulmonary resuscitation after cardiac arrest[J];Shandong Medical Journal;2013-20
5 Yu-Hong Zhang, Guo-Du Tang, Zhi-Yi Xu, Li Cai, Department of Gastroenterology, the First Affi liated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Zhuang Autonomous Region, China;Protective effects of edaravone against acute necrotizing pancreatitis in rats[J];World Chinese Journal of Digestology;2012-15
6 MAO Xiang-ying(Department of Neurology,the People′s Hospital of Changyuan City,Changyuan 453400,China);Clinical evaluation of edaravone for treatment of acute cerebral infarction[J];Journal of Xinxiang Medical College;2008-01
7 WANG Xiao-xiong (Medical Department of Heart,Qionghai People's Hospital,Qionghai HAINAN 571400,China);Effect of edaravone on serum matrix metalloproteinase 9 in patients with acute cerebral infarction[J];Chinese Journal of New Drugs and Clinical Remedies;2009-12
8 JIANG Ya-bin1,HUANG Li-an2,WANG Tong-ge2,HUANG Shun-shao2,CHEN Zhuo-ming2 1Emergency Department,2Department of Neurology,First Affiliated Hospital of Jinan University,Guangzhou 510630,Guangdong,China;Clinical observation on combining edaravone with breviscapine in treatment of patients with acute cerebral infarction[J];Chinese Journal of Clinical Pharmacology and Therapeutics;2009-07
9 Li Li,Zhou Yanan Department of Pharmacy,People's Hospital of Wuhan University,Wuhan 430060,China;Meta-analysis of Edaravone in Treatment of Acute Cerebral Infarction[J];Chinese Journal of Pharmacoepidemiology;2009-06
10 DENG Zhen,XIANG Yun-jie(Guizhou Xifeng County People's Hospital,Xifeng 551100,China);Advance in Research on Pharmacologic Action and Clinical Application of Edaravone Injection[J];Evaluation and Analysis of Drug-Use in Hospitals of China;2010-11
【Citations】
Chinese Journal Full-text Database 1 Hits
1 GU Xue-lan SUN Tao Jiangsu Simcere Pharmaceutical Institute,Nanjing JIA NGSU 210042,China GAO Yan-kun ZHU Dong-ya Department of Pharmacology,School of Pharmacy,Nanjing Medical University,Nanjing JIANGSU 210029,China;Effects of edaravone on score of neurological behavior,cerebral ischemia areas and amount of bleeding after cerebral hemorrhage in rats[J];Chinese Journal of New Drugs and Clinical Remedies;2006-05
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 YI Zhifeng,FANG Hao,CHENG Qian,WAGN Jie,ZHANG Ning,ZHANG Chuan(The neurosurgery department,The two Hospital of Huangshi Hubei Province,Huangshi,Hubei 435002,China);The Research of Traditional Chinese Medicine on Never Function and Cerebral Perfusion in Rats with Cerebral Hemorrhage[J];Journal of Traditional Chinese Medicine University of Hunan;2012-04
2 FENG Shuman,TENG Junfang The First Affiliated Hospital Zhengzhou University,Zhengzhou 450052,China;Edaravone In Treatment of Acute Cerebral Infarction[J];Journal of Medical Forum;2008-08
3 YIN You,XU Yun,ZHAN Qing,DONG Wan-li,ZHANG Xu,ZHANG Kun-nan,SUN Lin,KE Kai-fu,LIU Yu-min,YU Hao,XUE Ming,RUAN Jin-man,ZHAO Zhong-xin (1.Department of Nerology,Changzheng Hospital,the Second Military Medical University of PLA,SHANGHAI 200003,China;2.Department of Nerology,Gulou Hospital,the Medical School of Nanjing University, Nanjing JIANGSU 210008,China;3.Department oj Nerology,Tongji Hospital,the Tongji University, SHANGHAI 200065,China;4.Department of Nerology,the First Affiliated Hospital,the Suzhou University, Suzhou JIANGSU 215006,China;5.Department of Nerology,the First Affiliated Hospital,the Wenzhou Medical College,Wenzhou ZHEJIANG 325000,China;6.Department of Nerology,the Jiangxi Provincial People's Hospital,Nanchang JIANGXI 330006,China;7.Department of Nerology,the Second Hospital of Shandong University,Ji-nan SHANDONG 250033,China;8.Department of Nerology,Affiliated Hospital of Nantong University,Nantong JIANGSU 226001,China;9.Department of Nerology,Zhongnan Hospital of Wuhan University,Wuhan HUBEI 430077,China;10.Department of Epidemiology and Biostatistics,School of Public Health,Nanjing Medical University,Nanjing JIANGSU 210029,China;11.Yangtze River Pharmaceutical Group Nanjing Hailing Pharmaceutical Co.,Ltd,Nanjing JIANGSU 210049,China;12.Nanjing UDOW Technology Co.,Ltd.,Nanjing JIANGSU 210002,China);A randomized,double blind,and parallel controlled multicenter clinical trial on therapeutic window of edaravone in acute cerebral infarction[J];Chinese Journal of New Drugs and Clinical Remedies;2011-07
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Liu Lianggang,Song Jisheng,Shen Huaigui,Wu Biao Outpatient Department of off Duty Cadres Rest House,Lu'an Military Subarea Anhui Province Military Area,Hefei 237000;Hefei Jiunuo Pharmaceutical and Technological Co.Ltd,Hefei 230088;Safety evaluation of edaravone injection[J];Anhui Medical Journal;2011-09
2 YUAN Tong-qin(Department of Internal Medicine,Linquan People's Hospital,Linquan 236000,China);Treatment of transient ischemic attack with yidalaphon:a report of 45 cases[J];Anhui Medical and Pharmaceutical Journal;2008-04
3 ZHANG Hong1,ZHOU Min2,ZHANG Jun-jian1(1Department of Neurology,Zhong’nan Hospital of Wuhan University;Center for Cerebral Vascular Diseases,Medical College of Wuhan University,Wuhan 430071,China;2Department of Food Science and Technology,School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai 200240,China);The therapeutic effect of Shuxuening injection on acute cerebral infarction and its mechanism[J];China Journal of Traditional Chinese Medicine and Pharmacy;2009-01
4 LIU Jun LIU Yun-lin HUANG Shi-xiong LIU Zhong-lin XIAO Song-hua LI Yi HE Feng ZHOU Hai-hong XING Yi-gang. Department of Neurology,Second Affiliated Hospital,Sun Yat-sen University,Guangzhou 510120,China;Treatment of radiation encephalopathy with edaravone as a new brain protective agent[J];Chinese Journal of Neuromedicine;2006-08
5 TANG Xiao-rong WU Zhen-dong. Department of Neurology,Central Hospital of Chaozhou City,Chaozhou 521000,China;Therapeutic efficacy of edaravone-defibrase combination on acute brain infarction[J];Chinese Journal of Neuromedicine;2006-08
6 ;依达拉奉治疗重型颅脑损伤62例临床分析[J];Contemporary Medicine;2011-11
7 LIU Wen-jun1,2,JIA Yi-tao1,XIA Zhao-fan1,FU Jin-feng2,MA Bing1,L Kai-yang1,WEI Wei1 1.Department of Burns,Changhai Hospital,Second Military Medical University,Shanghai 200433,China2.Department of Burns,Second Affiliated Hospital of Kunming Medical College,Kunming 650101;Effect of tempol,a free radical scavenger,on p38 activation in rats with renal ischemia reperfusion injury[J];Academic Journal of Second Military Medical University;2008-02
8 LI Jing, FENG Hong-ye, REN Li-jie, HAN Man-fu, LIANG Yu-hong, CHEN Ting, BAI Run-tao (Department of Neurology, The Second People's Hospital of Shenzhen, Shenzhen 518035, China);Effects of a novel free radical scavenger edaravone on acute cerebral infarction[J];Acta Academiae Medicinae Militaris Tertiae;2005-07
9 TIAN Jialin (Department of Physiotherapy, Hong Kong Hospital of PLA, Shenzhen 518048, China);Effects of electric acupuncture therapy with early rehabilitation training on IL-6 and IL-1 in rats of cerebral ischemic injury[J];Acta Academiae Medicinae Militaris Tertiae;2005-14
10 Chen Bin1,Zuo Youbo1,Zhang Guoyuan2,Lai Yinglong3 (1Department of Anesthesiology,2Department of Clinical Laboratory,3Department of Thoracic Surgery,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan Province,637000,China);Role of edaravone in patients undergoing cardiac valve replacement under cardiopulmonary bypass:report of 30 cases[J];Acta Academiae Medicinae Militaris Tertiae;2010-14
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 ;氯吡格雷联合前列地尔治疗急性脑梗死的临床疗效观察[J];Contemporary Medicine;2012-03
2 San Xing-zhong,Lin Seng,Xu Shi-wei (The department of neurology in Fangxian County people's hospital of Hubei Province,Shiyan 442100,China);The Character of the Pathogens Distributed in the Stroke Patient in the Remote Rural Area Who Had the Complication of Urinary Tract Infection and the Analysis of the Resistance to Antibiotics[J];Chinese Journal of Medicinal Guide;2011-11
3 Huang Jie,Liao Jun,Zeng Hong-lian,et al.(Affiliated Hospital of Chengdu University,Chengdu 610081,China);Effect of Fluoxetine for Motor Recovery after Acute Cerebral Infarction[J];Chinese Journal of Medicinal Guide;2012-04
4 Zhan Sanhua,Zhang Lufeng,Yao Wemin,et al.(Department of Neurology,Armed Police Hospital of Henan,Zhengzhou 450052,China);Effective Observation of the Combination of Edaravone and Fibrinolysin in Treatment of Elderly Progressive Cerebral Infarction[J];Chinese Journal of Medicinal Guide;2012-05
5 Liao Shaohua1,Fan Qinlin2,Wu Ya1,Wang Haoxiang1,Chen Kangning1,Zhou Zhenhua1(1Department of Neurology,Southwest Hospital,Third Military Medical University,Chongqing,400038;2Department of Neurology,Xinqiao Hospital,Third Military Medical University,Chongqing,400037,China);EPCs transplantation in treatment of transient middle cerebral artery occlusion in rats[J];Journal of Third Military Medical University;2012-07
6 HAN Hu1,CHEN Ling1,HE Jia-yuan1,ZHENG Cheng-yao1,YU Tao2 1 Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China; 2 First Teaching Hospital of Tianjin University of TCM;Clinical Observation on Neutral Supplementation and Draining Method in Treating Hemiplegia Induced by Stroke at Ⅳ,Ⅴ or Ⅵ Stage Classified with Brunnstrom[J];Western Journal of Traditional Chinese Medicine;2012-06
7 LIU Ling-yu ,CHEN Bin,LV Zhi-hua,ZHANG Qing-an. Department of neurology,the First People's Hospital,Hubei 448000,China;Effects of Very Early Intra-arterial Thrombolytic Therapy for Patients with Acute Cerebral Infarction[J];Neural Injury and Functional Reconstruction;2011-04
8 Zhang Chen-hong(Nuclear Industry 215 Hospital,2thNeurology Department,Xianyang 712000,China);Intravenous Thrombolysis Combined with Local Mild Hypothermia Efficacy of the Treatment ofAcute Ischemic Stroke[J];Chinese Journal of Medicinal Guide;2012-08
9 SHI Gangji LIN Zitong TAN Daan Department of Neurosurgery,the People's Hospital of Huaiji County in Guangdong Province,Huaiji 526400,China;The effect of early application of edaravone on levels of serum CRP in treatment of patients with acute severe brain injury[J];China Medicine and Pharmacy;2013-14
10 Sun Gaohui,Gao Zhiqiang,Gao Junfeng,et al.Department of Neurology,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China;Intravenous thrombolysis with low dose urokinase for acute cerebral infarctions[J];Chinese Journal of Practical Nervous Diseases;2011-16
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHOU Qing-bo1,BI Jian-zhong1,LI Lu-yang2,SHAO Nian-fang3,JIA Qing4(1.Department of Neurology,Second Hospital of Shandong University,Jinan 250033,Shandong,China; 2.Department of Traditional Chinese Medicine,Qilu Hospital of Shandong University,Jinan 250012,Shandong,China; 3.Department of Amergency,Affiliated Hospital of Shandong Traditional Chinese Medicine University,Jinan 250012,Shandong,China; 4.Instifute of Preclinical Medicine,Shandong of Medical Sciences,Jinan 250012,Shandong,China);Effect of β-aescinate on changes of superoxide dismutase,nitrogen monoxide and tumor necrosis factor-α content in blood after intracerebral hemorrhage in rats[J];Journal of Shandong Univenity(Health Scicnes);2005-01
2 GU Xue-lan1, DING Xin-sheng2, DI Qing3, ZHAO Zhong-xin4, CHEN Jia-hui1, LI Jian-hua1 (1. SIMCERE Pharmaceutical Research Institute, Nanjing JIANGSU 210042,China; 2. Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing JIANGSU 210029,China; 3. Department of Neurology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing JIANGSU 210029,China; 4. Department of Neurology, Changzheng Hospital, SHANGHAI 200003, China);Efficacy evaluation of edaravone injection in treatment of acute cerebral infarction[J];Chinese Journal of New Drugs and Clinical Remedies;2005-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved