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《Chinese Journal of New Drugs and Clinical Remedies》 2009-05
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Effects of zedoary turmeric oil on proliferation and apoptosis of human breast cancer cell MCF-7

PU Lei1,ZHAO Shu-peng2(1.Liaoning Medical College,Jinzhou LIAONING 121001,China;2.Department of General Surgery,the First Affiliated Hospital of Liaoning Medical College,Jinzhou LIAONING 121001,China)  
AIM To investigate the effects of zedoary turmeric oil on proliferation and apoptosis of breast carcinoma cell MCF-7.METHODS MCF-7 was cultured to exponential phase of growth with different concentrations(150,200,250,300 and 400 mg·L-1) of zedoary turmeric oil.Cell viability optimized combination of drug concentration and time was chosen by MTT assay and inhibition rates were investigated.Apoptotic rates were determined by flow cytometry.The protein expression of Fas /FasL was determined by Western blot and immunocytochemical method,respectively.RESULTS Zedoary turmeric oil effectively inhibited the growth of MCF-7 in a concentration-dependent manner(P 0.05) .Compared with the control group,the cell apoptotic rates of the treated group increased significantly(P 0.01) .Zedoary turmeric oil up-regulated the expression of Fas protein and down-regulated that of FasL protein(P 0.05) .CONCLUSION Zedoary turmeric oil inhibits the proliferation and induces the apoptosis of MCF-7.The underlying mechanism may relate with the up-regulation of apoptotic protein Fas and the down-regulation of anti-apoptotic protein FasL.
【CateGory Index】: R737.9
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