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《Chinese Occupational Medicine》 2002-03
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Trichloroethylene-induced medicamentosa-like dermatitis and genetic polymorphism of xenobiotics metabolic enzymes: a case-control study

LI Lai-yu 1, LENG Shu-guang 2, ZHENG Yu-xin 2, HE Jia-xi 3, HUANG Jian-xun 1, HE Feng-sheng 21. Hospital for Occupational Diseases Control of Guangdong Province P.R. of China; 2. Institute of Occupational Medicine, Chinese Academy of Preventive Medi  
Objective To explore the susceptible gene of trichloroethylene-induced skin damage in occupational workers. Methods The genetic polymorphisms of CYP1A1, GSTM1, GSTP1, GSTT1 and NAT2 were analyzed in 43 patients and 47 healthy workers exposed to trichloroethylene and the odds ratios were calculated. Results The Kpn1 variant in NAT2 gene appeared to increase significantly the risk of trichloroethylene-induced dermatitis and subjects with slow NAT2 genotypes have significantly higher risk compared with those with wild type. No significance was found in term of other gene polymorphisms. Conclusion NAT2 gene polymorphism might be one of the factors influencing the individual susceptibility to Trichloroethylene-induced skin damage.
【Fund】: 广东省重点科技攻关项目 (编号 :962 2 0 56 - 0 5);; 广东省卫生系统“五个一科教兴医工程”重点科技项目 (编号 :1 996 - 1 86)~~
【CateGory Index】: R758.25
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