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《Chinese Occupational Medicine》 2005-06
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Effects of cadmium on steroidogenesis in chipped ovary culture in estrous cycle

HUANG Ya-qing,ZHANG Wen-chang,LI Huang-yuan,et al(Center for Disease Control and Prevention of Dongguan City,Dongguan 523016,China)  
Objective To study the toxic effects of cadmium in vitro and the estrous cycle on steroidogenesis in chipped ovary culture.Methods Two factorial experiments were designed to explore the influence of four dosage levels of cadmium(0,100,(1 000),(2 000) μmol/L) and four different stages(proestrous,estrous,postestrous,dioestrous) of estrous cycle on steroidogenesis in the ovary.Results In chipped ovary culture,effects of cadmium on estradiol secretion were significant(P0.05),particularly at the proestrous stage,showing obvious inhibition on estradiol secretion with a dose-effect curve.Effects of cadmium on progesterone secretion were not significant(P0.05).Effects of estrous cycle on estradiol and progesterone secretion in chipped ovary culture were significant(P0.001 and P0.05).Conclusion It is concluded that in this study,cadmium can elicit toxic effects on hormone secretion in chipped ovary culture at proestrous.
【CateGory Index】: R114
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