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《China Occupational Medicine》 2008-06
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A cohort study on the risk of previous chronic bronchitis and lung cancer in Yunnan tin miners

FAN Ya-guang,JIANG Yong,CHANG Run-sheng,et al(Institute of Radiation Medicine,Chinese Academy of Medical Sciences,Tianjin 300192,China)  
Objective To investigate the relationship between previous chronic bronchitis and lung cancer in Yunnan tin miners.Methods A prospective analysis using COX regression method was conducted to discuss the relationship between previous chronic bronchitis and lung cancer death risk in Yunnan tin miners.Results From 1992 to 1999,totally 9 295 eligible tin miners were enrolled to the cohort study,and by the end of 2001,443 lung cancer deaths were confirmed.COX regression results showed that previous chronic bronchitis increased the risk of lung cancer death significantly,when the analysis was conducted according histology,the linkage was significant with squamous cell lung cancer,and there was no significant relationship between previous chronic bronchitis and adenocarcinoma or small cell lung cancer.Results of stratified analysis suggested that the previous chronic bronchitis increased lung cancer risk significantly only among smokers.Conclusion Previous chronic bronchitis might be an important cause of lung cancer in this occupational-based cohort study.
【Fund】: 中美合作课题(NCI-263-MQ511694)
【CateGory Index】: R562.21;R734.2
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