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《China Occupational Medicine》 2010-05
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Effects of some anesthetics on blood gas,serum electrolytes and biochemical indexes in female SD rats

LAI Guan-chao,LIU Zhen-zhong,HE Kang-wen,CHEN Keng-keng,GE Yi-chen,SUI Gang,LI Hong-ling,TANG Xiao-jiang(Guangdong Prevention and Treatment Center for Occupational Diseases,Guangzhou 510300,China)  
Objective To study the effects of anesthetics,pentobarbital sodium,ethylcarbamate and ether,on blood gas,serum electrolytes and biochemical indexes in female SD rats.Methods Rats were randomly divided into 4 groups with 9 animals per group which were treated with normal saline(NS),pentobarbital sodium,ethylcarbamate and ether,respectively.Blood gas was analyzed with arterial blood taken from left ventricular,while serum electrolytes and biochemical indexes were checked with blood taken from eye fossa orbitalis plexus.Results Compared with the NS group,the indexes of total CO2(TCO2),HCO-3,base excess of extracellidar fluid(BE),serum phosphste(P) and urea increased while serum K+,Na+,total protein(TP),albmin(ALB) and total bilirubin(TBIL) declined in rats injected with pentobarbital sodium.The indexes of pH,partial pressure of oxygen(PO2) and serum glucose(GLU) increased,but serum K+,Na+,P,alanine aminotransferase(ALT),aspartate aminotransferase(AST),lactic dehydrogenase(LDH),creatine kinase(CK),hydroxybutyrate dehydrogenase(HBDH),TP,ALB,TBIL declined in rats treated with ethylcarbamate.Serum Ca2+ and GLU increased while serum K+,P,ALT,AST,LDH,CK,HBDH,uric acid(UA) and TBIL declined in ether group.Conclusion Anesthetics,like pentobarbital sodium,ethylcarbamate and ether,could decrease the serum K+ level and change serum Na+,blood gas and biochemical indexes in female SD rats.
【Fund】: 国家自然科学基金项目(30771786 30972458);; 中国博士后科学基金(20060400224);; 广东省自然科学基金项目(06023421);; 广东省医学科研基金项目(B1999010 B2002005 A2004060 A2005067B2006009 B2007012 A2007058 A2009060)
【CateGory Index】: Q95-33
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