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《China Occupational Medicine》 2011-02
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Effect of chlorpyrifos on spermatogenesis function and sex hormone levels of male rats

LI Xiang-xin,SAI Lin-lin,XIE Lin,LIU Yan-zhong,YU Gong-chang,LIU Yi(Shandong Academy of Occupational Health and Occupational Medicine,Jinan 250002,China)  
Objective To explore the effects of chlorpyrifos on spermatogenesis function and sex hormone levels of male rats.Methods 40 male Wistar rats,clean degree,were divided into four groups,the control(0 mg·kg-1·d-1),low(2.7 mg·kg-1·d-1),moderate(5.4 mg·kg-1·d-1)and high dose groups(12.8 mg·kg-1·d-1).The rats were treated with chlorpyrifos by gavage,once a day for 90 consecutive days.Simultaneously,the controls were treated with equivalent volume of distilled water and tween-80.Then,the testis,epididymides and prostates-seminal vesicles were immediately excised and weighed,and the viscera coefficients were calculated.The number and motility of sperms in the tail of epididymis,the sex hormone levels were tested.Results In the moderate and high-dose groups,the numbers and motilities of sperms were significantly decreased,while the sperm abnormality rates were increased(P0.05),serum testosterone levels were markedly decreased while serum FSH levels were increased(P0.05).There were no significant differences between different groups of serum luteinizing hormone and estrogen.Conclusion Chlorpyrifos can produce reproductive toxicity in male rats,affecting their spermatogenesis function and sex hormone levels.
【CateGory Index】: R114
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