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《Chinese Journal of Heart and Heart Rhythm(Electronic Edition)》 2018-02
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Curative effect of sofren injection on unstable angina pectoris and its influence on platelet function

Li Jianli;Cheng Jiangtao;Department of Cardiology,Henan Provincial People’s Hospital;  
Objective To study the curative effect of sofren injection on unstable angina pectoris and its influence on platelet function. Methods A total of 76 patients with unstable angina pectoris admitted to Henan Provincial People's Hospital from July of 2016 to December of 2017 were randomly divided into control group and observation group,38 cases in each group. The control group received routine drug treatment,while the observation group received sofren injection on the basis of routine drug treatment. The curative effect,plasma plasminogen activator inhibitor 1( PAI-1),thromboxane B2( TXB2),platelet aggregation rate before and after treatment were compared between the two groups. Results The total effective rate was 71. 05%( 27/38) in the control group and 92. 11%( 35/38) in the observation group,and the difference was statistically significant( P 0. 05). After treatment for 4 weeks,the levels of PAI-1,TXB2 and platelet aggregation rate in the observation group were lower than those in the control group( P 0. 05). Conclusion Sofren injection can effectively alleviate the symptoms of patients with unstable angina pectoris and improve platelet function,which is worthy of clinical promotion.
【Fund】: 2016年河南省医学科技攻关计划项目
【CateGory Index】: R259
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