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《Acta Academiae Medicinae Xuzhou》 2006-02
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Experimental study on the protective effects of creatine phosphate and L-arginine on donor heart in rats

QIAN Wei-min,ZHANG Zhong-ming,ZHANG Wei,et al(Department of Cardiothoracic Surgery,Affiliated Hospital of Xuzhou Medical College,Xuzhou,Jiangsu 221002,China)  
Objective To investigate the effects of creatine phosphate(CP) and L-arginine(L-arg) on the preservation of donor heart in rats.?Methods Forty rats were randomly allocated into 4 groups to get the hearts preserved for 480 min with 4℃ cardioplegic solution(control group),with cardioplegic solution plus CP(group 1),with cardioplegic plus L-arg(group 2) and with cardioplegic plus CP and L-arg(group 3).The donor heart was transplanted into the neck of recipient rat.Left ventricular tissue was removed 24 h after transplantation to determine the contents of SOD,ATPase and MDA,and to study the myocardial ultrastructure.?Results Arrhythmia was much less frequent in group 3 than in control group,group 1 and group 2.The contents of SOD and ATPase were higher,but the content of MDA was lower in group 3 than in the other 3 groups.The damages in myocardial ultrastructure were also less severe in group 3.?Conclusion Exogenous CP and L-arg could significantly enhance the cardioplegia effects.
【Fund】: 徐州医学院附属医院科研课题资助项目(2002209)
【CateGory Index】: R96
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