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《Acta Academiae Medicinae Xuzhou》 2006-04
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The protective role of endogenous nitric oxide in rat gastric ischemia/reperfusion injury

QIAO Wei-li,WANG Lin,ZHANG Jian-fu,et al(Department of Physiology,Xuzhou Medical College,Xuzhou,Jiangsu 221002,China)  
Objective To investigate the protective role of endogenous nitric oxide(NO) in gastric ischemia/reperfusion(GI/R) injury of rats.?Methods The GI/R model was established by clamping the celiac artery for 30 min and allowing reperfusion for 3 h.The effects of L-arginine(NO synthesis precursor) and N-nitro-L-arginine(L-NAME,NO synthetase blocker) on gastric mucosal cellular injury,apoptosis and proliferation were observed by using histological and immunohistochemical methods in SD rats.?Results In the L-arginine group,the gastric mucosal cellular injury induced by GI/R was significantly alleviated,with the gastric mucosal injury area and apoptotic cells decreased and the proliferative cells increased(P0.05).However,In the L-NAME group,the gastric mucosal cellular injury was significantly aggravated,showing increase of gastric mucosal injury area and number of apoptotic cells and decrease of proliferative cells(P0.05).?Conclusion The endogenous nitric oxide plays a protective role against gastric ischemia/reperfusion injury in rats
【Fund】: 国家自然科学基金资助项目(30370533);; 江苏省高校自然科学研究指导性计划项目(02KJD310008);; 徐州医学院科研课题资助项目(04KJ17)
【CateGory Index】: R573
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