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《Journal of Xuzhou Medical University》 2019-09
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Expression and clinical significance of neuropilin-1 in EGFR positive lung adenocarcinoma

YANG Zhonghuan;WANG Hongmei;DU Xiuping;HAN Zhengxiang;Department of Oncology,the Affiliated Hospital of Xuzhou Medical University;  
Objective To explore the expression and clinical significance of neuropilin-1(NRP-1) in epidermal growth factor receptor(EGFR)-positive lung adenocarcinoma.Methods Fifty cases with positive EGFR mutation and 28 cases with negative EGFR mutation were screened.The expression of NRP-1 and VEGFR2 was detected by immunohistochemistry.The correlation between clinical parameters and NRP-1 and VEGFR2 was analyzed.Results The positive expression rates of NRP-1 and VEGFR2 in EGFR mutant positive lung adenocarcinoma were significantly higher than those in EGFR mutant negative lung adenocarcinoma(P 0.05).The expression of NRP-1 and VEGFR2 in EGFR-positive lung adenocarcinoma was correlated with the size of tumors,TNM stage,differentiation degree of tumors and lymph node metastasis(P 0.05),but not with age and sex(P 0.05).Kaplan-Meier survival curve showed that progression-free survival(PFS) in low-expression group of NRP-1 and VEGFR2 was significantly longer than that in high-expression group(P0.05).The expression of NRP-1 and VEGFR2 was positively correlated.COX multivariate analysis showed that both NRP-1 and VEGFR2 were independent risk factors for poor prognosis of EGFR positive lung adenocarcinoma patients(P0.05).Conclusions NRP-1 is highly expressed in EGFR-positive lung adenocarcinoma tissues.NRP-1 plays an important role in the occurrence,development and metastasis of lung adenocarcinoma.NRP-1 may be a new target for targeted therapy of EGFR-positive lung adenocarcinoma.
【Fund】: 江苏省“六大人才高峰”B类项目(2014-WSW-040);; 江苏省科教强卫创新团队(CXTDA2017034)
【CateGory Index】: R734.2
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