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《Journal of Xuzhou Medical University》 2019-09
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Expression and clinical significance of miR-197 in the serum of prostate cancer patients

LI Li;WANG Sugui;YAN Yao;HAN Zhengxiang;School of Clinical Medicine,Xuzhou Medical University;Department of Urology,Huai'an Hospital Affiliated of Xuzhou Medical University;Department of Urology,Huaiyin Hospital of Huai'an;  
Objective To investigate the expression of microRNA-197(miR-197) in the serum of prostate cancer patients and its clinical significance.Methods Real-time fluorescence quantitative polymerase chain reaction(qPCR) was used to detect the relative expression of serum miR-197 in 48 prostate cancer patients,48 patients with benign prostatic hyperplasia and 48 healthy subjects.The relationship between the relative expression of serum miR-197 and clinicopathological characteristics was analyzed.The receiver operating characteristic(ROC) curve was plotted to analyze the sensitivity and specificity of serum miR-197 in the diagnosis of prostate cancer.Results The level of serum miR-197 in prostate cancer patients was higher than that in benign prostatic hyperplasia and healthy subjects(P 0.05).However,there was no significant difference in the level of serum miR-197 between benign prostatic hyperplasia patients and healthy subjects(P0.05).The level of serum miR-197 was significantly correlated with clinical pathological stage,Gleason score and bone metastasis of prostate cancer(P 0.05),rather than age and prostate specific antigen(P0.05).ROC curve showed that miR-197 could differentiate prostate cancer from benign prostatic hyperplasia and healthy subjects,with the area under the curve was 0.828(95% Cl:0.794-0.919) and 0.809(95% Cl:0.746-0.918),respectively.Conclusions The high expression of miR-197 in the serum of prostate cancer patients is related to the progression of prostate cancer,and can be used as a marker to determine the prognosis of prostate cancer.
【Fund】: 江苏省科教强卫放疗创新团队(CXTDA2017034);; 淮安市自然科学基金(HAB201730);; 徐州医科大学附属淮安医院科研基金(YK201506)
【CateGory Index】: R737.25
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