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《Chinese Pharmacological Bulletin》 1989-03
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EFFECT OF 4-PHOSP ATE-HYDROXYPIPERAQUINE ON THE ISOLATED AURICAL OF GUINEA PIG

Li Husong & Zhao Gengsheng ( Dept. of Pharmacology, Xian Medical University, Shanxi)  
The effect of 4 -Phosphate- lydroxypiperaquine ( PHPQ) on the phsiologic properties in isolated auricle of guinea pig was studied. Twenty minutes after PHPQ 30 μmol/L was added, the contractility dT/dtmax of the left atria of guinea pig were decreased to 74.4 ± ( SD ) 5.3%(n=6, P0.01) 73,8±4.9% (n=6, P0.01) resp- ectively, the functional refractory period ( FRP ) was prolonged from 139.4±26.7 ms to 214.8±27.8 ms (n=9, P0.01), the duration -intensity curve was shifted remrkably to up-right direction ( n= 8 , P0.01) the epinephrine concentration inducing automaticity was increased from 33.4±6.2μmol/L to 106.9±21.6 μmol/L (n=7, P 0.0l). Furthermore ,30 μmol/L PHPQ could decrease the spontaneous beating rate from 148±16 beat/min to 142±15 beat/min (n=6, P 0.01). The results suggest that PHPQ might be antagonistic to Na+ in current also influence the utility of Ca2+ . The decrease of automaticity excitability . the prolongation of FRP are thought to be related to its antiarrhythmic action.
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【References】
Chinese Journal Full-text Database 2 Hits
1 LI Hu-Song,ZHAO Geng-Sheng(Inst Clinical Pharmacology,Xian Medical University,Xian 710061);Effect of hydroxypiperaquine phosphate on action potential and contractive force of guinea pig's heart muscles[J];Chinese Journal of Pharmacology and Toxicology;1990-03
2 LI Hu-Song,ZHAO Geng-Sheng,LI Xiao-Guang(Inst Clinical Pharmacology,Xian Medical University,Xian 710061);Effect of hydroxypiperaquine phosphate on the slow response action potential in guinea-pig papillary muscles and rabbit sinus node cells[J];Chinese Journal of Pharmacology and Toxicology;1990-03
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 Shen Nianci, et al (Laboratory for Antimalarial Drug Research);ACUTE TOXICITY OF HYDROXYPIPERAQUINE[J];Academic Journal of Second Military Medical University;1989-04
2 SONG Jianping;CHEN Peiquan;XU Ying;OU Fengzhen;TAN Bo;LI Guoqiao Tropical Medicine Institute, Guangzhou University of TCM, Guangzhou 510405, China Affiliated Yuehai Hospital of Guangzhou University of TCM, Sanya, Hainan 572021, China;Randomized-Cootrol Trial of Compound Dihydroartemisinin in Treating Uncomplicated Falciparum Malaria in Hainan Province of China[J];Journal of Guangzhou University of Traditional Chinese Medicine;2004-01
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